doi:10.3390/nu11061340engBarja-Fernández S.Folgueira C.Castelao C.Pena-León V.González-Saenz P.Vázquez-Cobela R.Aguilera C.M.Gil-Campos M.Bueno G.Gil Á.Moreno L.A.Ruiz-Piñon M.García-Palacios M.Casanueva F.F.Diéguez C.Nogueiras R.Leis R.Seoane L.M.ANGPTL-4 is associated with obesity and lipid profile in children and adolescentsART-2019-115082Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and a_ects energy homeostasis. However, its function in children with obesity remains unknown. We investigated plasma ANGPTL-4 levels in children and its relationship with body mass index (BMI) and di_erent lipidic parameters such as free fatty acids (FFA). Plasma ANGPTL-4 levels were analyzed in two di_erent cohorts. In the first cohort (n = 150, age 3-17 years), which included children with normal weight or obesity, we performed a cross-sectional study. In the second cohort, which included only children with obesity (n = 20, age 5-18 years) followed up for two years after an intervention for weight loss, in which we performed a longitudinal study measuring ANGPTL-4 before and after BMI-loss. In the cross-sectional study, circulating ANGPTL-4 levels were lower in children with obesity than in those with normal weight. Moreover, ANGPTL-4 presented a negative correlation with BMI, waist circumference, weight, insulin, homeostasis model assessment of insulin resistance index (HOMA index), triglycerides, and leptin, and a positive correlation with FFA and vitamin-D. In the longitudinal study, the percent change in plasma ANGPTL-4 was correlated with the percent change in FFA, total-cholesterol and high-density lipoprotein cholesterol. This study reveals a significant association of ANGPTL-4 with pediatric obesity and plasma lipid profile.2019http://zaguan.unizar.es/record/8639010.3390/nu11061340http://zaguan.unizar.es/record/86390oai:zaguan.unizar.es:86390info:eu-repo/grantAgreement/ES/ISCIII/PI11-02042info:eu-repo/grantAgreement/ES/ISCIII/PI15-01272info:eu-repo/grantAgreement/ES/ISCIII/PI16-00871info:eu-repo/grantAgreement/ES/ISCIII/PI16-01301info:eu-repo/grantAgreement/ES/ISCIII/PI18-00998NUTRIENTS 11, 6 (2019), 1340 [14 pp.]byhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccess