86390 20220525082806.0 doi 10.3390/nu11061340 sideral 115082 ART-2019-115082 eng Barja-Fernández S. ANGPTL-4 is associated with obesity and lipid profile in children and adolescents 2019 Access copy available to the general public Unrestricted Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and a_ects energy homeostasis. However, its function in children with obesity remains unknown. We investigated plasma ANGPTL-4 levels in children and its relationship with body mass index (BMI) and di_erent lipidic parameters such as free fatty acids (FFA). Plasma ANGPTL-4 levels were analyzed in two di_erent cohorts. In the first cohort (n = 150, age 3-17 years), which included children with normal weight or obesity, we performed a cross-sectional study. In the second cohort, which included only children with obesity (n = 20, age 5-18 years) followed up for two years after an intervention for weight loss, in which we performed a longitudinal study measuring ANGPTL-4 before and after BMI-loss. In the cross-sectional study, circulating ANGPTL-4 levels were lower in children with obesity than in those with normal weight. Moreover, ANGPTL-4 presented a negative correlation with BMI, waist circumference, weight, insulin, homeostasis model assessment of insulin resistance index (HOMA index), triglycerides, and leptin, and a positive correlation with FFA and vitamin-D. In the longitudinal study, the percent change in plasma ANGPTL-4 was correlated with the percent change in FFA, total-cholesterol and high-density lipoprotein cholesterol. This study reveals a significant association of ANGPTL-4 with pediatric obesity and plasma lipid profile. info:eu-repo/grantAgreement/ES/ISCIII/PI11-02042 info:eu-repo/grantAgreement/ES/ISCIII/PI15-01272 info:eu-repo/grantAgreement/ES/ISCIII/PI16-00871 info:eu-repo/grantAgreement/ES/ISCIII/PI16-01301 info:eu-repo/grantAgreement/ES/ISCIII/PI18-00998 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.546 2019 NUTRITION & DIETETICS 17 / 89 = 0.191 2019 Q1 T1 1.329 2019 Nutrition and Dietetics 2019 Q1 Food Science 2019 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Folgueira C. Castelao C. Pena-León V. González-Saenz P. Vázquez-Cobela R. Aguilera C.M. Gil-Campos M. Bueno G. Universidad de Zaragoza (orcid)0000-0002-0902-387X Gil Á. Moreno L.A. Universidad de Zaragoza (orcid)0000-0003-0454-653X Ruiz-Piñon M. García-Palacios M. Casanueva F.F. Diéguez C. Nogueiras R. Leis R. Seoane L.M. 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1010 670 Universidad de Zaragoza Dpto. Pediatría Radiol.Med.Fís Área Pediatría 11, 6 (2019), 1340 [14 pp.] NUTRIENTS NUTRIENTS 2072-6643 649891 http://zaguan.unizar.es/record/86390/files/texto_completo.pdf Versión publicada 110758 http://zaguan.unizar.es/record/86390/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:86390 articulos driver 2022-05-25-08:25:29 ARTICLE