000086397 001__ 86397
000086397 005__ 20230914083243.0
000086397 0247_ $$2doi$$a10.3390/jcm8091471
000086397 0248_ $$2sideral$$a114800
000086397 037__ $$aART-2019-114800
000086397 041__ $$aeng
000086397 100__ $$aAnguita-Ruiz, Augusto
000086397 245__ $$aCommon Variants in 22 Genes Regulate Response to Metformin Intervention in Children with Obesity: A Pharmacogenetic Study of a Randomized Controlled Trial
000086397 260__ $$c2019
000086397 5060_ $$aAccess copy available to the general public$$fUnrestricted
000086397 5203_ $$aMetformin is a first-line oral antidiabetic agent that has shown additional effects in treating obesity and metabolic syndrome. Inter-individual variability in metformin response could be partially explained by the genetic component. Here, we aimed to test whether common genetic variants can predict the response to metformin intervention in obese children. The study was a multicenter and double-blind randomized controlled trial that was stratified according to sex and pubertal status in 160 children with obesity. Children were randomly assigned to receive either metformin (1g/d) or placebo for six months after meeting the defined inclusion criteria. We conducted a post hoc genotyping study in 124 individuals (59 placebo, 65 treated) comprising finally 231 genetic variants in candidate genes. We provide evidence for 28 common variants as promising pharmacogenetics regulators of metformin response in terms of a wide range of anthropometric and biochemical outcomes, including body mass index (BMI) Z-score, and glucose, lipid, and inflammatory traits. Although no association remained statistically significant after multiple-test correction, our findings support previously reported variants in metformin transporters or targets as well as identify novel and promising loci, such as the ADYC3 and the BDNF genes, with plausible biological relation to the metformin''s action mechanism.
000086397 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/RETICS-RD12-0026-0015$$9info:eu-repo/grantAgreement/ES/MSCBS/EC10-227
000086397 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000086397 590__ $$a3.303$$b2019
000086397 591__ $$aMEDICINE, GENERAL & INTERNAL$$b36 / 165 = 0.218$$c2019$$dQ1$$eT1
000086397 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000086397 700__ $$aPastor-Villaescusa, Belén
000086397 700__ $$aLeis, Rosaura
000086397 700__ $$0(orcid)0000-0002-0902-387X$$aBueno, Gloria$$uUniversidad de Zaragoza
000086397 700__ $$aHoyos, Raúl
000086397 700__ $$aVazquez-Cobela, Rocío
000086397 700__ $$aLatorre-Millan, Miriam
000086397 700__ $$aCañete, M. Dolores
000086397 700__ $$aCaballero-Villarraso, Javier
000086397 700__ $$aGil, Ángel
000086397 700__ $$aCañete, Ramón
000086397 700__ $$aAguilera, Concepción M.
000086397 7102_ $$11010$$2670$$aUniversidad de Zaragoza$$bDpto. Pediatría Radiol.Med.Fís$$cÁrea Pediatría
000086397 773__ $$g8, 9 (2019), 1471 [20 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000086397 8564_ $$s813915$$uhttps://zaguan.unizar.es/record/86397/files/texto_completo.pdf$$yVersión publicada
000086397 8564_ $$s110719$$uhttps://zaguan.unizar.es/record/86397/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000086397 909CO $$ooai:zaguan.unizar.es:86397$$particulos$$pdriver
000086397 951__ $$a2023-09-13-10:49:41
000086397 980__ $$aARTICLE