000086400 001__ 86400
000086400 005__ 20210526094600.0
000086400 0247_ $$2doi$$a10.1186/s13567-019-0702-7
000086400 0248_ $$2sideral$$a114835
000086400 037__ $$aART-2019-114835
000086400 041__ $$aeng
000086400 100__ $$aRoy, Álvaro
000086400 245__ $$aEvaluation of the immunogenicity and efficacy of BCG and MTBVAC vaccines using a natural transmission model of tuberculosis
000086400 260__ $$c2019
000086400 5060_ $$aAccess copy available to the general public$$fUnrestricted
000086400 5203_ $$aEffective vaccines against tuberculosis (TB) are needed in order to prevent TB transmission in human and animal populations. Evaluation of TB vaccines may be facilitated by using reliable animal models that mimic host pathophysiology and natural transmission of the disease as closely as possible. In this study, we evaluated the immunogenicity and efficacy of two attenuated vaccines, BCG and MTBVAC, after each was given to 17 goats (2 months old) and then exposed for 9 months to goats infected with M. caprae. In general, MTBVAC-vaccinated goats showed higher interferon-gamma release than BCG vaccinated goats in response to bovine protein purified derivative and ESAT-6/CFP-10 antigens and the response was significantly higher than that observed in the control group until challenge. All animals showed lesions consistent with TB at the end of the study. Goats that received either vaccine showed significantly lower scores for pulmonary lymph nodes and total lesions than unvaccinated controls. Both MTBVAC and BCG vaccines proved to be immunogenic and effective in reducing severity of TB pathology caused by M. caprae. Our model system of natural TB transmission may be useful for evaluating and optimizing vaccines.
000086400 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/IJCI-2015-24805$$9info:eu-repo/grantAgreement/ES/MINECO/IPT2012-0327-090000
000086400 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000086400 590__ $$a3.357$$b2019
000086400 591__ $$aVETERINARY SCIENCES$$b6 / 142 = 0.042$$c2019$$dQ1$$eT1
000086400 592__ $$a1.425$$b2019
000086400 593__ $$aVeterinary (miscellaneous)$$c2019$$dQ1
000086400 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000086400 700__ $$aTomé, Irene
000086400 700__ $$aRomero, Beatriz
000086400 700__ $$aLorente-Leal, Víctor
000086400 700__ $$aInfantes-Lorenzo, José A.
000086400 700__ $$aDomínguez, Mercedes
000086400 700__ $$0(orcid)0000-0003-2993-5478$$aMartín, Carlos$$uUniversidad de Zaragoza
000086400 700__ $$0(orcid)0000-0001-7897-9173$$aAguiló, Nacho$$uUniversidad de Zaragoza
000086400 700__ $$aPuentes, Eugenia
000086400 700__ $$aRodríguez, Esteban
000086400 700__ $$aDe Juan, Lucía
000086400 700__ $$aRisalde, María A.
000086400 700__ $$aGortázar, Christian
000086400 700__ $$aDomínguez, Lucas
000086400 700__ $$aBezos, Javier
000086400 7102_ $$11008$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Microbiología
000086400 773__ $$g50, 82 (2019), s13567-019-0702-7 [13 pp.]$$pVet. res.$$tVeterinary Research$$x0928-4249
000086400 8564_ $$s1158968$$uhttps://zaguan.unizar.es/record/86400/files/texto_completo.pdf$$yVersión publicada
000086400 8564_ $$s111385$$uhttps://zaguan.unizar.es/record/86400/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000086400 909CO $$ooai:zaguan.unizar.es:86400$$particulos$$pdriver
000086400 951__ $$a2021-05-26-09:32:17
000086400 980__ $$aARTICLE