000086401 001__ 86401
000086401 005__ 20210526094600.0
000086401 0247_ $$2doi$$a10.1186/s12931-019-1167-y
000086401 0248_ $$2sideral$$a114837
000086401 037__ $$aART-2019-114837
000086401 041__ $$aeng
000086401 100__ $$aPinto-Plata, Víctor
000086401 245__ $$aPlasma metabolomics and clinical predictors of survival differences in COPD patients
000086401 260__ $$c2019
000086401 5060_ $$aAccess copy available to the general public$$fUnrestricted
000086401 5203_ $$aBackground: Plasma metabolomics profile (PMP) in COPD has been associated with clinical characteristics, but PMP''s relationship to survival has not been reported. We determined PMP differences between patients with COPD who died an average of 2 years after enrollment (Non-survivors, NS) compared to those who survived (S) and also with age matched controls (C). Methods: We studied prospectively 90 patients with severe COPD and 30 controls. NS were divided in discovery and validation cohorts (30 patients each) and the results compared to the PMP of 30 S and C. All participants completed lung function tests, dyspnea scores, quality of life, exercise capacity, BODE index, and plasma metabolomics by liquid and gas chromatography/mass spectometry (LC/MS, LC/MS2, GC/MS). Statistically, we used Random Forest Analysis (RFA) and Support Vector Machine (SVM) to determine metabolites that differentiated the 3 groups and compared the ability of metabolites vs. clinical characteristics to classify patients into survivors and non-survivors. Results: There were 79 metabolites statistically different between S and NS [p < 0.05 and false discovery rate (q value) < 0.1]. RFA and SVM classification of COPD survivors and non-survivors had a predicted accuracy of 74 and 85% respectively. Elevation of tricyclic acid cycle intermediates branched amino acids depletion and increase in lactate, fructose and xylonate showed the most relevant differences between S vs. NS suggesting alteration in mitochondrial oxidative energy generation. PMP had similar predictive power for risk of death as information provided by clinical characteristics. Conclusions: A plasma metabolomic profile characterized by an oxidative energy production difference between survivors and non-survivors was observed in COPD patients 2 years before death.
000086401 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000086401 590__ $$a3.924$$b2019
000086401 591__ $$aRESPIRATORY SYSTEM$$b18 / 64 = 0.281$$c2019$$dQ2$$eT1
000086401 592__ $$a1.436$$b2019
000086401 593__ $$aPulmonary and Respiratory Medicine$$c2019$$dQ1
000086401 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000086401 700__ $$aCasanova, Ciro
000086401 700__ $$aDivo, Miguel
000086401 700__ $$aTesfaigzi, Yohannes
000086401 700__ $$aCalhoun, Vince
000086401 700__ $$aSui, Jing
000086401 700__ $$aPolverino, Francesca
000086401 700__ $$aPriolo, Carmen
000086401 700__ $$aPetersen, Hans
000086401 700__ $$aDe Torres, Juan Pablo
000086401 700__ $$0(orcid)0000-0001-9096-2294$$aMarín, José María$$uUniversidad de Zaragoza
000086401 700__ $$aOwen, Caroline A.
000086401 700__ $$aBaz, Rebeca
000086401 700__ $$aCordova, Elizabeth
000086401 700__ $$aCelli, Bartolome
000086401 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000086401 773__ $$g20, 219 (2019), s12931-019-1167-y [8 pp.]$$pRespir. res.$$tRespiratory research$$x1465-9921
000086401 8564_ $$s1401085$$uhttps://zaguan.unizar.es/record/86401/files/texto_completo.pdf$$yVersión publicada
000086401 8564_ $$s100276$$uhttps://zaguan.unizar.es/record/86401/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000086401 909CO $$ooai:zaguan.unizar.es:86401$$particulos$$pdriver
000086401 951__ $$a2021-05-26-09:32:20
000086401 980__ $$aARTICLE