000086440 001__ 86440
000086440 005__ 20200103150048.0
000086440 0247_ $$2doi$$a10.1016/j.addr.2018.12.008
000086440 0248_ $$2sideral$$a109619
000086440 037__ $$aART-2018-109619
000086440 041__ $$aeng
000086440 100__ $$aRoca, A.G.
000086440 245__ $$aDesign strategies for shape-controlled magnetic iron oxide nanoparticles
000086440 260__ $$c2018
000086440 5060_ $$aAccess copy available to the general public$$fUnrestricted
000086440 5203_ $$aFerrimagnetic iron oxide nanoparticles (magnetite or maghemite) have been the subject of an intense research, not only for fundamental research but also for their potentiality in a widespread number of practical applications. Most of these studies were focused on nanoparticles with spherical morphology but recently there is an emerging interest on anisometric nanoparticles. This review is focused on the synthesis routes for the production of uniform anisometric magnetite/maghemite nanoparticles with different morphologies like cubes, rods, disks, flowers and many others, such as hollow spheres, worms, stars or tetrapods. We critically analyzed those procedures, detected the key parameters governing the production of these nanoparticles with particular emphasis in the role of the ligands in the final nanoparticle morphology. The main structural and magnetic features as well as the nanotoxicity as a function of the nanoparticle morphology are also described. Finally, the impact of each morphology on the different biomedical applications (hyperthermia, magnetic resonance imaging and drug delivery) are analysed in detail. We would like to dedicate this work to Professor Carlos J. Serna, Instituto de Ciencia de Materiales de Madrid, ICMM/CSIC, for his outstanding contribution in the field of monodispersed colloids and iron oxide nanoparticles. We would like to express our gratitude for all these years of support and inspiration on the occasion of his retirement.
000086440 536__ $$9info:eu-repo/grantAgreement/ES/CSIC/PIE-201760E007$$9info:eu-repo/grantAgreement/EC/FP7/604448/EU/Nanometrology Standardization Methods for Magnetic Nanoparticles/NANOMAG$$9info:eu-repo/grantAgreement/ES/MINECO/MAT2016-77391-R$$9info:eu-repo/grantAgreement/ES/MINECO/MAT2017-88148-R$$9info:eu-repo/grantAgreement/ES/MINECO/RYC-2014-15512$$9info:eu-repo/grantAgreement/ES/MINECO/SEV-2017-0706
000086440 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000086440 590__ $$a15.519$$b2018
000086440 591__ $$aPHARMACOLOGY & PHARMACY$$b3 / 266 = 0.011$$c2018$$dQ1$$eT1
000086440 592__ $$a4.163$$b2018
000086440 593__ $$aPharmaceutical Science$$c2018$$dQ1
000086440 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000086440 700__ $$0(orcid)0000-0003-2366-3598$$aGutiérrez, L.$$uUniversidad de Zaragoza
000086440 700__ $$aGavilán, H.
000086440 700__ $$aFortes Brollo, M.E.
000086440 700__ $$aVeintemillas-Verdaguer, S.
000086440 700__ $$aMorales, M.D.P.
000086440 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000086440 773__ $$g138, 1 (2018), 68-104$$pAdv. drug deliv. rev.$$tADVANCED DRUG DELIVERY REVIEWS$$x0169-409X
000086440 8564_ $$s1277173$$uhttps://zaguan.unizar.es/record/86440/files/texto_completo.pdf$$yPostprint
000086440 8564_ $$s40797$$uhttps://zaguan.unizar.es/record/86440/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000086440 909CO $$ooai:zaguan.unizar.es:86440$$particulos$$pdriver
000086440 951__ $$a2020-01-03-13:57:43
000086440 980__ $$aARTICLE