000086472 001__ 86472
000086472 005__ 20240104111813.0
000086472 0247_ $$2doi$$a10.4103/1673-5374.270299
000086472 0248_ $$2sideral$$a115320
000086472 037__ $$aART-2020-115320
000086472 041__ $$aeng
000086472 100__ $$0(orcid)0000-0001-5193-7782$$aCalvo, Ana Cristina$$uUniversidad de Zaragoza
000086472 245__ $$aType XIX collagen: a promising biomarker from the basement membranes
000086472 260__ $$c2020
000086472 5060_ $$aAccess copy available to the general public$$fUnrestricted
000086472 5203_ $$aAmong collagen members in the collagen superfamily, type XIX collagen has raised increasing interest in relation to its structural and biological roles. Type XIX collagen is a Fibril-Associated Collagen with Interrupted Triple helices member, one main subclass of collagens in this superfamily. This collagen contains a triple helix composed of three polypeptide segments aligned in parallel and it is associated with the basement membrane zone in different tissues. The molecular structure of type XIX collagen consists of five collagenous domains, COL1 to COL5, interrupted by six non-collagenous domains, NC1 to NC6. The most relevant domain by which this collagen exerts its biological roles is NC1 domain that can be cleavage enzymatically to release matricryptins, exerting anti-tumor and anti-angiogenic effect in murine and human models of cancer. Under physiological conditions, type XIX collagen expression decreases after birth in different tissues although it is necessary to keep its basal levels, mainly in skeletal muscle and hippocampal and telencephalic interneurons in brain. Notwithstanding, in amyotrophic lateral sclerosis, altered transcript expression levels show a novel biological effect of this collagen beyond its structural role in basement membranes and its anti-tumor and anti-angiogenic properties. Type XIX collagen can exert a compensatory effect to ameliorate the disease progression under neurodegenerative conditions specific to amyotrophic lateral sclerosis in transgenic SOD1G93A mice and amyotrophic lateral sclerosis patients. This novel biological role highlights its nature as prognostic biomarker of disease progression in and as promising therapeutic target, paving the way to a more precise prognosis of amyotrophic lateral sclerosis.
000086472 536__ $$9info:eu-repo/grantAgreement/ES/FIS-FEDER/PI17-00949
000086472 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-sa$$uhttp://creativecommons.org/licenses/by-nc-sa/3.0/es/
000086472 590__ $$a5.135$$b2020
000086472 591__ $$aNEUROSCIENCES$$b78 / 273 = 0.286$$c2020$$dQ2$$eT1
000086472 591__ $$aCELL BIOLOGY$$b78 / 195 = 0.4$$c2020$$dQ2$$eT2
000086472 592__ $$a0.93$$b2020
000086472 593__ $$aDevelopmental Neuroscience$$c2020$$dQ2
000086472 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000086472 700__ $$0(orcid)0000-0002-7277-4318$$aMoreno, Laura
000086472 700__ $$0(orcid)0000-0003-2436-7205$$aMoreno, Leticia$$uUniversidad de Zaragoza
000086472 700__ $$0(orcid)0000-0002-7243-1737$$aToivonen, Janne$$uUniversidad de Zaragoza
000086472 700__ $$0(orcid)0000-0002-7477-8742$$aManzano, Raquel$$uUniversidad de Zaragoza
000086472 700__ $$aMolina, Nora
000086472 700__ $$0(orcid)0000-0002-7955-7164$$ade la Torre, Miriam$$uUniversidad de Zaragoza
000086472 700__ $$0(orcid)0000-0001-9802-8199$$aLopez, Tresa$$uUniversidad de Zaragoza
000086472 700__ $$0(orcid)0000-0001-5981-5448$$aMiana-Mena, Francisco Javier$$uUniversidad de Zaragoza
000086472 700__ $$aMuñoz, María Jesús
000086472 700__ $$0(orcid)0000-0001-5740-0185$$aZaragoza, Pilar$$uUniversidad de Zaragoza
000086472 700__ $$0(orcid)0000-0001-6199-2953$$aLarrodé, Pilar$$uUniversidad de Zaragoza
000086472 700__ $$aGarcía-Redondo, Alberto
000086472 700__ $$0(orcid)0000-0001-5687-6704$$aOsta, Rosario$$uUniversidad de Zaragoza
000086472 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000086472 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000086472 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000086472 773__ $$g15, 6 (2020), 988-995$$pNEURAL REGENERATION RESEARCH$$tNEURAL REGENERATION RESEARCH$$x1673-5374
000086472 8564_ $$s1464960$$uhttps://zaguan.unizar.es/record/86472/files/texto_completo.pdf$$yVersión publicada
000086472 8564_ $$s1697$$uhttps://zaguan.unizar.es/record/86472/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000086472 909CO $$ooai:zaguan.unizar.es:86472$$particulos$$pdriver
000086472 951__ $$a2024-01-04-11:03:22
000086472 980__ $$aARTICLE