87540 20200716101434.0 doi 10.1016/j.atherosclerosis.2019.01.024 sideral 110894 ART-2019-110894 eng Bea, A.M. Lipid-lowering response in subjects with the p.(Leu167del) mutation in the APOE gene 2019 Access copy available to the general public Unrestricted Background and aims: The aim of this work was to compared the effect of lipid lowering drugs among familial hypercholesterolemia (FH) subjects with a functional mutation in LDLR (LDLR FH) and FH with the p.(Leu167del) mutation in APOE. Methods: We retrospectively selected all adults with the p.(Leu167del) mutation on lipid-lowering treatment (n = 22) attending the Lipid Unit at the Hospital Miguel Servet. Age and sex matched LDLR FH from the same Unit were randomly selected as a control group (n = 44). Results: The mean percentage reduction in LDLc was significantly higher in the p.(Leu167del) carriers (-52.1%) than in the LDLR FH (-39.7%) (p = 0.040) when on high intensity statins. Similar differences between groups were observed in non-HDLc -49.4% and -36.4%, respectively (p = 0.030). Conclusions: Subjects with p.(Leu167del) mutation have a higher lipid-lowering response to statins with or without ezetimibe than LDLR FH. This supports the use of genetics for a more efficient management of FH. info:eu-repo/grantAgreement/EUR/ISCII-ERDF/A way to make Europe info:eu-repo/grantAgreement/ES/MINECO/PI13-02507 info:eu-repo/grantAgreement/ES/MINECO/PI15-01983 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.919 2019 1.515 2019 PERIPHERAL VASCULAR DISEASE 16 / 65 = 0.246 2019 Q1 T1 Cardiology and Cardiovascular Medicine 2019 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS 42 / 138 = 0.304 2019 Q2 T1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Lamiquiz-Moneo, I. Marco-Benedí, V. (orcid)0000-0001-6650-8294 Mateo-Gallego, R. Universidad de Zaragoza Pérez-Calahorra, S. (orcid)0000-0001-9142-0737 Jarauta, E. Universidad de Zaragoza Martín, C. Cenarro, A. (orcid)0000-0001-7043-0952 Civeira, F. Universidad de Zaragoza 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 282 (2019), 143-147 Atherosclerosis Atherosclerosis 0021-9150 156287 http://zaguan.unizar.es/record/87540/files/texto_completo.pdf Postprint 190982 http://zaguan.unizar.es/record/87540/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:87540 articulos driver 2020-07-16-08:53:13 ARTICLE