000087549 001__ 87549
000087549 005__ 20220309092436.0
000087549 0247_ $$2doi$$a10.1002/mabi.201800397
000087549 0248_ $$2sideral$$a110409
000087549 037__ $$aART-2019-110409
000087549 041__ $$aeng
000087549 100__ $$0(orcid)0000-0002-5823-0314$$aSoria-Carrera, H.
000087549 245__ $$aPolypeptidic Micelles Stabilized with Sodium Alginate Enhance the Activity of Encapsulated Bedaquiline
000087549 260__ $$c2019
000087549 5060_ $$aAccess copy available to the general public$$fUnrestricted
000087549 5203_ $$aThe coating of polypeptidic micelles with sodium alginate is described as a strategy to improve the stability of micelles for drug delivery. Bedaquiline, approved in 2012 for the treatment of multidrug resistant tuberculosis, has been used as an example of hydrophobic drug to study the loading efficiency, the release of the encapsulated drug in different media, and the in vitro antimicrobial activity of the system. Alginate coating prevents the burst release of the drug from micelles upon dilution and leads to a sustained release in all tested media. In view of possible oral administration, the alginate coated micelles show better stability in gastric and intestinal simulated media. Notably, the encapsulated bedaquiline shows increased in vitro activity against Mycobacterium tuberculosis compared to free bedaquiline.
000087549 536__ $$9info:eu-repo/grantAgreement/ES/DGA/FSE$$9info:eu-repo/grantAgreement/ES/MINECO/RYC-2013-12570$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2015-66869-P
000087549 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000087549 590__ $$a3.416$$b2019
000087549 591__ $$aPOLYMER SCIENCE$$b17 / 89 = 0.191$$c2019$$dQ1$$eT1
000087549 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b130 / 297 = 0.438$$c2019$$dQ2$$eT2
000087549 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b18 / 38 = 0.474$$c2019$$dQ2$$eT2
000087549 592__ $$a0.834$$b2019
000087549 593__ $$aMaterials Chemistry$$c2019$$dQ1
000087549 593__ $$aPolymers and Plastics$$c2019$$dQ1
000087549 593__ $$aBiomaterials$$c2019$$dQ2
000087549 593__ $$aBioengineering$$c2019$$dQ2
000087549 593__ $$aBiotechnology$$c2019$$dQ2
000087549 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000087549 700__ $$0(orcid)0000-0002-0111-4697$$aLucía, A.$$uUniversidad de Zaragoza
000087549 700__ $$0(orcid)0000-0001-6995-4302$$aDe Matteis, L.
000087549 700__ $$0(orcid)0000-0003-2076-844X$$aAínsa, J.A.$$uUniversidad de Zaragoza
000087549 700__ $$0(orcid)0000-0003-1081-8482$$ade la Fuente, J.M.
000087549 700__ $$0(orcid)0000-0003-0702-8260$$aMartín-Rapún, R.$$uUniversidad de Zaragoza
000087549 7102_ $$11008$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Microbiología
000087549 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000087549 773__ $$g19, 4 (2019), 1800397 [11 pp]$$pMacromol. biosci.$$tMacromolecular Bioscience$$x1616-5187
000087549 8564_ $$s683355$$uhttps://zaguan.unizar.es/record/87549/files/texto_completo.pdf$$yPostprint
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000087549 951__ $$a2022-03-09-09:17:34
000087549 980__ $$aARTICLE