000087555 001__ 87555
000087555 005__ 20210902121601.0
000087555 0247_ $$2doi$$a10.1016/j.clnu.2019.01.013
000087555 0248_ $$2sideral$$a110678
000087555 037__ $$aART-2020-110678
000087555 041__ $$aeng
000087555 100__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, M.$$uUniversidad de Zaragoza
000087555 245__ $$aThe inflammatory potential of diet is related to incident frailty and slow walking in older adults
000087555 260__ $$c2020
000087555 5060_ $$aAccess copy available to the general public$$fUnrestricted
000087555 5203_ $$aBackground: Certain foods and dietary patterns have been associated with both inflammation and frailty. As chronic inflammation may play a role in frailty and disability, we examined the association of the inflammatory potential of diet with these outcomes.
Methods: Data were taken from 1948 community-dwelling individuals =60 years old from the Seniors-ENRICA cohort, who were recruited in 2008–2010 and followed-up through 2012. Baseline diet data, obtained with a validated diet history, was used to calculate Shivappa's Dietary Inflammatory Index (DII), an “a priori” pattern score which is based on known associations of foods and nutrients with inflammation, and Tabung's Empirical Dietary Inflammatory Index (EDII), an “a posteriori” pattern score which was statistically derived from an epidemiological study. At follow-up, incident frailty was assessed with Fried's criteria, and incident limitation in instrumental activities of daily living (IADL) with the Lawton-Brody index. Statistical analyses were performed with logistic regression, and adjusted for the main confounders.
Results: Compared with individuals in the lowest tertile of DII, those in the highest tertile showed higher risk of frailty (odds ratio [OR] 2.48; 95% confidence interval [CI]: 1.42, 4.44, p-trend = 0.001) and IADL disability (OR: 1.96; 95% CI: 1.03, 3.86, p-trend = 0.035). By contrast, EDII did not show an association with these outcomes. The DII score was associated with slow gait speed, both as a low score in the Short Physical Performance Battery test (OR: 1.82; 95% CI: 1.27, 2.62, p-trend = 0.001) and as a positive Fried's criterion (OR: 1.64; 95% CI: 1.08, 2.51, p-trend = 0.021), which use different thresholds.
Conclusions: DII predicted frailty and IADL while EDII did not. DII is able to measure diet healthiness in terms of physical decline in addition to avoidance of inflammation.
000087555 536__ $$9info:eu-repo/grantAgreement/EC/FP7/305483/EU/Utility of omic-based biomarkers in characterizing older individuals at risk for frailty, its progression to disability and general consequences to health and well-being - The FRAILOMIC Initiative/FRAILOMIC$$9info:eu-repo/grantAgreement/EC/H2020/635316/EU/Ageing Trajectories of Health: Longitudinal Opportunities and Synergies/ATHLOS$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 635316-ATHLOS$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI13-0288$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI14-00009$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI16-00609$$9info:eu-repo/grantAgreement/EUR/JPI-HDHL/SALAMANDER
000087555 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000087555 590__ $$a7.324$$b2020
000087555 591__ $$aNUTRITION & DIETETICS$$b7 / 88 = 0.08$$c2020$$dQ1$$eT1
000087555 592__ $$a1.915$$b2020
000087555 593__ $$aNutrition and Dietetics$$c2020$$dQ1
000087555 593__ $$aCritical Care and Intensive Care Medicine$$c2020$$dQ1
000087555 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000087555 700__ $$aRodriguez-Artalejo, F.
000087555 700__ $$aGuallar-Castillon, P.
000087555 700__ $$aBanegas, J.R.
000087555 700__ $$aGraciani, A.
000087555 700__ $$aGarcia-Esquinas, E.
000087555 700__ $$aLopez-Garcia, E.
000087555 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000087555 773__ $$g39, 1 (2020), 185-191$$pClin. nutr.$$tClinical Nutrition$$x0261-5614
000087555 8564_ $$s397484$$uhttps://zaguan.unizar.es/record/87555/files/texto_completo.pdf$$yPostprint
000087555 8564_ $$s62880$$uhttps://zaguan.unizar.es/record/87555/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000087555 909CO $$ooai:zaguan.unizar.es:87555$$particulos$$pdriver
000087555 951__ $$a2021-09-02-08:34:53
000087555 980__ $$aARTICLE