87570 20210902121611.0 doi 10.3390/antiox9010017 sideral 115749 ART-2020-115749 eng Mármol, Inés A combination of Rosa canina extracts and gold complex favors apoptosis of caco-2 cells by increasing oxidative stress and mitochondrial dysfunction 2020 Access copy available to the general public Unrestricted Given the alarming increase in colorectal cancer (CRC) worldwide, novel therapies are urgently needed. Plant-derived extracts have gained considerable interest in the last years due to their strong anticancer effect mediated by their unique bioactive compounds. Specifically, rosehips from Rosa canina have been successfully tested against several cancer models, including colon cancer. Moreover, gold derivatives are a promising alternative to the current platinum-based drugs commonly used in CRC chemotherapy due to their lack of affinity for DNA. Herein we have investigated the antitumor potential of a drug combination made of acidic polyphenols extracted from R. canina and the gold complex (Au(C=C-2-NC5H4) (PTA)) in Caco-2 cell line as a model of CRC. The combination triggered strong apoptosis mediated by a blockage of the autophagic flux, which might be a consequence of a reactive oxygen species (ROS) increase and mitochondrial dysfunctionality. Our results suggest that the clinical application of plant polyphenols might enhance the anticancer effect of metallodrugs and reduce drug exposure time and therefore its side effects. info:eu-repo/grantAgreement/ES/DGA/B16-R17 info:eu-repo/grantAgreement/ES/DGA/E07-17R info:eu-repo/grantAgreement/EUR/INTERREG-POCTEFA/EFA 220-11-ELENA info:eu-repo/grantAgreement/ES/ISCIII/CB06-03-1012 info:eu-repo/grantAgreement/ES/MINECO/CTQ2016-75816-C2-1-P info:eu-repo/grantAgreement/ES/MINECO/SAF2016-75441-R info:eu-repo/grantAgreement/EUR/SUDOE/INTERREG/Redvalue-SOE1-PI-E0123 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 6.312 2020 BIOCHEMISTRY & MOLECULAR BIOLOGY 60 / 297 = 0.202 2020 Q1 T1 FOOD SCIENCE & TECHNOLOGY 11 / 144 = 0.076 2020 Q1 T1 CHEMISTRY, MEDICINAL 6 / 63 = 0.095 2020 Q1 T1 1.066 2020 Biochemistry 2020 Q2 Cell Biology 2020 Q2 Physiology 2020 Q2 Molecular Biology 2020 Q2 Clinical Biochemistry 2020 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Jiménez-Moreno, Nerea Ancín-Azpilicueta, Carmen Osada, Jesús Universidad de Zaragoza (orcid)0000-0002-8251-8457 Cerrada, Elena Universidad de Zaragoza (orcid)0000-0003-2457-3674 Rodríguez-Yoldi, María Jesús Universidad de Zaragoza (orcid)0000-0002-3595-7668 2010 760 Universidad de Zaragoza Dpto. Química Inorgánica Área Química Inorgánica 1005 410 Universidad de Zaragoza Dpto. Farmacología y Fisiolog. Área Fisiología 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 9, 1 (2020), 17 [12 pp.] Antioxidants Antioxidants 2076-3921 815211 http://zaguan.unizar.es/record/87570/files/texto_completo.pdf Versión publicada 103999 http://zaguan.unizar.es/record/87570/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:87570 articulos driver 2021-09-02-08:41:17 ARTICLE