000087585 001__ 87585
000087585 005__ 20200716101539.0
000087585 0247_ $$2doi$$a10.1186/s13071-019-3852-6
000087585 0248_ $$2sideral$$a115786
000087585 037__ $$aART-2019-115786
000087585 041__ $$aeng
000087585 100__ $$aMatei, I.A.
000087585 245__ $$aA review on the eco-epidemiology and clinical management of human granulocytic anaplasmosis and its agent in Europe
000087585 260__ $$c2019
000087585 5060_ $$aAccess copy available to the general public$$fUnrestricted
000087585 5203_ $$aAnaplasma phagocytophilum is the agent of tick-borne fever, equine, canine and human granulocytic anaplasmosis. The common route of A. phagocytophilum transmission is through a tick bite, the main vector in Europe being Ixodes ricinus. Despite the apparently ubiquitous presence of the pathogen A. phagocytophilum in ticks and various wild and domestic animals from Europe, up to date published clinical cases of human granulocytic anaplasmosis (HGA) remain rare compared to the worldwide status. It is unclear if this reflects the epidemiological dynamics of the human infection in Europe or if the disease is underdiagnosed or underreported. Epidemiologic studies in Europe have suggested an increased occupational risk of infection for forestry workers, hunters, veterinarians, and farmers with a tick-bite history and living in endemic areas. Although the overall genetic diversity of A. phagocytophilum in Europe is higher than in the USA, the strains responsible for the human infections are related on both continents. However, the study of the genetic variability and assessment of the difference of pathogenicity and infectivity between strains to various hosts has been insufficiently explored to date. Most of the European HGA cases presented as a mild infection, common clinical signs being pyrexia, headache, myalgia and arthralgia. The diagnosis of HGA in the USA was recommended to be based on clinical signs and the patient''s history and later confirmed using specialized laboratory tests. However, in Europe since the majority of cases are presenting as mild infection, laboratory tests may be performed before the treatment in order to avoid antibiotic overuse. The drug of choice for HGA is doxycycline and because of potential for serious complication the treatment should be instituted on clinical suspicion alone.
000087585 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000087585 590__ $$a2.824$$b2019
000087585 591__ $$aTROPICAL MEDICINE$$b3 / 23 = 0.13$$c2019$$dQ1$$eT1
000087585 591__ $$aPARASITOLOGY$$b9 / 39 = 0.231$$c2019$$dQ1$$eT1
000087585 592__ $$a1.406$$b2019
000087585 593__ $$aParasitology$$c2019$$dQ1
000087585 593__ $$aInfectious Diseases$$c2019$$dQ1
000087585 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000087585 700__ $$0(orcid)0000-0001-7483-046X$$aEstrada-Peña, A.$$uUniversidad de Zaragoza
000087585 700__ $$aCutler, S.J.
000087585 700__ $$aVayssier-Taussat, M.
000087585 700__ $$aVarela-Castro, L.
000087585 700__ $$aPotkonjak, A.
000087585 700__ $$aZeller, H.
000087585 700__ $$aMihalca, A.D.
000087585 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000087585 773__ $$g12 (2019), 599 [19 pp.]$$pParasites & Vectors$$tParasites and Vectors$$x1756-3305
000087585 8564_ $$s1910018$$uhttps://zaguan.unizar.es/record/87585/files/texto_completo.pdf$$yVersión publicada
000087585 8564_ $$s101631$$uhttps://zaguan.unizar.es/record/87585/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000087585 909CO $$ooai:zaguan.unizar.es:87585$$particulos$$pdriver
000087585 951__ $$a2020-07-16-09:39:13
000087585 980__ $$aARTICLE