000087621 001__ 87621
000087621 005__ 20210820090346.0
000087621 0247_ $$2doi$$a10.3389/fphys.2019.01465
000087621 0248_ $$2sideral$$a115846
000087621 037__ $$aART-2019-115846
000087621 041__ $$aeng
000087621 100__ $$aOrini, Michele
000087621 245__ $$aThe Effect of Emotional Valence on Ventricular Repolarization Dynamics Is Mediated by Heart Rate Variability: A Study of QT Variability and Music-Induced Emotions
000087621 260__ $$c2019
000087621 5060_ $$aAccess copy available to the general public$$fUnrestricted
000087621 5203_ $$aBackground: Emotions can affect cardiac activity, but their impact on ventricular repolarization variability, an important parameter providing information about cardiac risk and autonomic nervous system activity, is unknown. The beat-to-beat variability of the QT interval (QTV) from the body surface ECG is a non-invasive marker of repolarization variability, which can be decomposed into QTV related to RR variability (QTVrRRV) and QTV unrelated to RRV (QTVuRRV), with the latter thought to be a marker of intrinsic repolarization variability. Aim: To determine the effect of emotional valence (pleasant and unpleasant) on repolarization variability in healthy volunteers by means of QTV analysis. Methods: 75 individuals (24.5 ± 3.2 years, 36 females) without a history of cardiovascular disease listened to music-excerpts that were either felt as pleasant (n = 6) or unpleasant (n = 6). Excerpts lasted about 90 s and were presented in a random order along with silent intervals (n = 6). QTV and RRV were derived from the ECG and the time-frequency spectrum of RRV, QTV, QTVuRRV and QTVrRRV as well as time-frequency coherence between QTV and RRV were estimated. Analysis was performed in low-frequency (LF), high frequency (HF) and total spectral bands. Results: The heart rate-corrected QTV showed a small but significant increase from silence (median 347/interquartile range 31 ms) to listening to music felt as unpleasant (351/30 ms) and pleasant (355/32 ms). The dynamic response of QTV to emotional valence showed a transient phase lasting about 20 s after the onset of each musical excerpt. QTV and RRV were highly correlated in both HF and LF (mean coherence ranging 0.76–0.85). QTV and QTVrRRV decreased during listening to music felt as pleasant and unpleasant with respect to silence and further decreased during listening to music felt as pleasant. QTVuRRV was small and not affected by emotional valence. Conclusion: Emotional valence, as evoked by music, has a small but significant effect on QTV and QTVrRRV, but not on QTVuRRV. This suggests that the interaction between emotional valence and ventricular repolarization variability is mediated by cycle length dynamics and not due to intrinsic repolarization variability.
000087621 536__ $$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/RTI2018-097723-B-I00$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/T39-17R-BSICoS
000087621 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000087621 590__ $$a3.367$$b2019
000087621 591__ $$aPHYSIOLOGY$$b20 / 81 = 0.247$$c2019$$dQ1$$eT1
000087621 592__ $$a1.211$$b2019
000087621 593__ $$aPhysiology (medical)$$c2019$$dQ2
000087621 593__ $$aPhysiology$$c2019$$dQ2
000087621 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000087621 700__ $$aAl-Amodi, Faez
000087621 700__ $$aKoelsch, Stefan
000087621 700__ $$0(orcid)0000-0003-1272-0550$$aBailón, Raquel$$uUniversidad de Zaragoza
000087621 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000087621 773__ $$g10 (2019), 1465 1-9$$pFront. physiol.$$tFRONTIERS IN PHYSIOLOGY$$x1664-042X
000087621 8564_ $$s8521076$$uhttps://zaguan.unizar.es/record/87621/files/texto_completo.pdf$$yVersión publicada
000087621 8564_ $$s22385$$uhttps://zaguan.unizar.es/record/87621/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000087621 909CO $$ooai:zaguan.unizar.es:87621$$particulos$$pdriver
000087621 951__ $$a2021-08-20-08:38:19
000087621 980__ $$aARTICLE