000087623 001__ 87623 000087623 005__ 20200716101548.0 000087623 0247_ $$2doi$$a10.3389/fgene.2019.01170 000087623 0248_ $$2sideral$$a115852 000087623 037__ $$aART-2019-115852 000087623 041__ $$aeng 000087623 100__ $$0(orcid)0000-0002-1335-7610$$aMouresan, Elena F. 000087623 245__ $$aMapping Recombination Rate on the Autosomal Chromosomes Based on the Persistency of Linkage Disequilibrium Phase Among Autochthonous Beef Cattle Populations in Spain 000087623 260__ $$c2019 000087623 5060_ $$aAccess copy available to the general public$$fUnrestricted 000087623 5203_ $$aIn organisms with sexual reproduction, genetic diversity, and genome evolution are governed by meiotic recombination caused by crossing-over, which is known to vary within the genome. In this study, we propose a simple method to estimate the recombination rate that makes use of the persistency of linkage disequilibrium (LD) phase among closely related populations. The biological material comprised 171 triplets (sire/dam/offspring) from seven populations of autochthonous beef cattle in Spain (Asturiana de los Valles, Avileña-Negra Ibérica, Bruna dels Pirineus, Morucha, Pirenaica, Retinta, and Rubia Gallega), which were genotyped for 777, 962 SNPs with the BovineHD BeadChip. After standard quality filtering, we reconstructed the haplotype phases in the parental individuals and calculated the LD by the correlation -r- between each pair of markers that had a genetic distance < 1 Mb. Subsequently, these correlations were used to calculate the persistency of LD phase between each pair of populations along the autosomal genome. Therefore, the distribution of the recombination rate along the genome can be inferred since the effect of the number of generations of divergence should be equivalent throughout the genome. In our study, the recombination rate was highest in the largest chromosomes and at the distal portion of the chromosomes. In addition, the persistency of LD phase was highly heterogeneous throughout the genome, with a ratio of 25.4 times between the estimates of the recombination rates from the genomic regions that had the highest (BTA18-7.1 Mb) and the lowest (BTA12-42.4 Mb) estimates. Finally, an overrepresentation enrichment analysis (ORA) showed differences in the enriched gene ontology (GO) terms between the genes located in the genomic regions with estimates of the recombination rate over (or below) the 95th (or 5th) percentile throughout the autosomal genome. 000087623 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/AGL2010-15903$$9info:eu-repo/grantAgreement/ES/MINECO/BES-2011-045434 000087623 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000087623 590__ $$a3.258$$b2019 000087623 591__ $$aGENETICS & HEREDITY$$b73 / 177 = 0.412$$c2019$$dQ2$$eT2 000087623 592__ $$a1.469$$b2019 000087623 593__ $$aMolecular Medicine$$c2019$$dQ1 000087623 593__ $$aGenetics$$c2019$$dQ2 000087623 593__ $$aGenetics (clinical)$$c2019$$dQ2 000087623 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000087623 700__ $$0(orcid)0000-0001-9869-524X$$aGonzález-Rodríguez, Aldemar 000087623 700__ $$aCañas-Álvarez, J.Jacobo 000087623 700__ $$aMunilla, Sebastián 000087623 700__ $$0(orcid)0000-0002-3042-2250$$aAltarriba, Juan$$uUniversidad de Zaragoza 000087623 700__ $$aDíaz, Clara 000087623 700__ $$aBaró, Jesús A. 000087623 700__ $$aMolina, Antonio 000087623 700__ $$0(orcid)0000-0001-5992-2913$$aLopez-Buesa, Pascual$$uUniversidad de Zaragoza 000087623 700__ $$aPiedrafita, Jesús 000087623 700__ $$0(orcid)0000-0001-6256-5478$$aVarona, Luis$$uUniversidad de Zaragoza 000087623 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética 000087623 7102_ $$12008$$2780$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Tecnología de Alimentos 000087623 773__ $$g10 (2019), 1170 1-12$$pFront. genet.$$tFrontiers in Genetics$$x1664-8021 000087623 8564_ $$s3007940$$uhttps://zaguan.unizar.es/record/87623/files/texto_completo.pdf$$yVersión publicada 000087623 8564_ $$s104449$$uhttps://zaguan.unizar.es/record/87623/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000087623 909CO $$ooai:zaguan.unizar.es:87623$$particulos$$pdriver 000087623 951__ $$a2020-07-16-09:44:05 000087623 980__ $$aARTICLE