000087634 001__ 87634 000087634 005__ 20200716101551.0 000087634 0247_ $$2doi$$a10.1186/s13567-019-0714-3 000087634 0248_ $$2sideral$$a115864 000087634 037__ $$aART-2019-115864 000087634 041__ $$aeng 000087634 100__ $$aAragón-Aranda, Beatriz 000087634 245__ $$aRev1 wbdR tagged vaccines against Brucella ovis 000087634 260__ $$c2019 000087634 5060_ $$aAccess copy available to the general public$$fUnrestricted 000087634 5203_ $$aSheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B. melitensis serodiagnosis, which precludes its use against B. ovis where B. melitensis is absent. In mice, Rev1 deleted in wbkC (Brucella lipopolysaccharide formyl-transferase) and carrying wbdR (E. coli acetyl-transferase) triggered antibodies that could be differentiated from those evoked by wild-type strains, was comparatively attenuated and protected against B. ovis, suggesting its potential as a B. ovis vaccine. 000087634 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/AGL2014-58795-C4-1-R$$9info:eu-repo/grantAgreement/ES/MINECO/BES-2015-075609 000087634 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000087634 590__ $$a3.357$$b2019 000087634 591__ $$aVETERINARY SCIENCES$$b6 / 142 = 0.042$$c2019$$dQ1$$eT1 000087634 592__ $$a1.425$$b2019 000087634 593__ $$aVeterinary (miscellaneous)$$c2019$$dQ1 000087634 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000087634 700__ $$aDe Miguel, María Jesús 000087634 700__ $$aMartínez-Gómez, Estrella 000087634 700__ $$aZúñiga-Ripa, Amaia 000087634 700__ $$aSalvador-Bescós, Miriam 000087634 700__ $$aMoriyón, Ignacio 000087634 700__ $$aIriarte, Maite 000087634 700__ $$0(orcid)0000-0002-7970-4929$$aMuñoz, Pilar M. 000087634 700__ $$aConde-Álvarez, Raquel 000087634 773__ $$g50 (2019), 95 [9 pp.]$$pVet. res.$$tVeterinary Research$$x0928-4249 000087634 8564_ $$s1368413$$uhttps://zaguan.unizar.es/record/87634/files/texto_completo.pdf$$yVersión publicada 000087634 8564_ $$s112311$$uhttps://zaguan.unizar.es/record/87634/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000087634 909CO $$ooai:zaguan.unizar.es:87634$$particulos$$pdriver 000087634 951__ $$a2020-07-16-09:46:10 000087634 980__ $$aARTICLE