87634 20200716101551.0 doi 10.1186/s13567-019-0714-3 sideral 115864 ART-2019-115864 eng Aragón-Aranda, Beatriz Rev1 wbdR tagged vaccines against Brucella ovis 2019 Access copy available to the general public Unrestricted Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B. melitensis serodiagnosis, which precludes its use against B. ovis where B. melitensis is absent. In mice, Rev1 deleted in wbkC (Brucella lipopolysaccharide formyl-transferase) and carrying wbdR (E. coli acetyl-transferase) triggered antibodies that could be differentiated from those evoked by wild-type strains, was comparatively attenuated and protected against B. ovis, suggesting its potential as a B. ovis vaccine. info:eu-repo/grantAgreement/ES/MINECO/AGL2014-58795-C4-1-R info:eu-repo/grantAgreement/ES/MINECO/BES-2015-075609 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.357 2019 VETERINARY SCIENCES 6 / 142 = 0.042 2019 Q1 T1 1.425 2019 Veterinary (miscellaneous) 2019 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion De Miguel, María Jesús Martínez-Gómez, Estrella Zúñiga-Ripa, Amaia Salvador-Bescós, Miriam Moriyón, Ignacio Iriarte, Maite (orcid)0000-0002-7970-4929 Muñoz, Pilar M. Conde-Álvarez, Raquel 50 (2019), 95 [9 pp.] Vet. res. Veterinary Research 0928-4249 1368413 http://zaguan.unizar.es/record/87634/files/texto_completo.pdf Versión publicada 112311 http://zaguan.unizar.es/record/87634/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:87634 articulos driver 2020-07-16-09:46:10 ARTICLE