87700 20200716101449.0 doi 10.1039/c8dt00298c sideral 111275 ART-2019-111275 eng Fernández-Moreira, V. Bioactive and luminescent indole and isatin based gold(i) derivatives 2019 Access copy available to the general public Unrestricted A series of luminescent monometallic [AuL(PPh 3 )] (1-3) and bimetallic [Au 2 (µ-dppe)L 2 ] (4, 6, 8) and [Au 2 (µ-dppp)L 2 ] (5, 7, 9) complexes, where L is either 4-cyano-indole, isatin, or 5, 7-dimethyl-isatin, and dppe and dppp are 1, 2-bis(diphenylphosphino)ethane and 1, 3-bis(diphenylphosphino)propane, respectively, have been synthesised. X-ray diffraction confirmed the tendency to establish aurophillic interations for those complexes containing dppe. Luminescence studies and theoretical calculations revealed a different origin for both families, i.e. indole and isatin species. Thus, indole derivatives presented a ligand-to-ligand-charge-transfer transition (LLCT) from the indole to the PPh 3 fragment, whereas for the isatin derivatives an intraligand-charge-transfer transition (ILCT) within the isatin fragment is proposed. In both cases, the gold centre was slightly implicated as a ligand-to-metal-charge transfer transition (LMCT) (from the indole/isatin to Au(i)). Cell antiproliferative assays in lung cancer cells (A549), leukemia Jurkat-pLVTHM and Jurkat-shBak cells (cisplatin sensitive and resistant, respectively) showed excellent cytotoxic values (10.11-0.28 µM), showing the leukemia cells to be the most sensitive and the bimetallic species to be the most active agents. Preliminary studies associated the cytotoxicity with a combination of different factors, the metallic fragment being mainly responsible. Remarkably, these complexes are able to inhibit the cellular growth of cisplatin resistant Jurkat-shBak cells highlighting their promising future as an alternative anticancer agent. info:eu-repo/grantAgreement/ES/DGA-FSE/E07-17R info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2016-75816-C2-1-P info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2017-88091-P info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 4.174 2019 CHEMISTRY, INORGANIC & NUCLEAR 5 / 45 = 0.111 2019 Q1 T1 1.048 2019 Inorganic Chemistry 2019 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Val-Campillo, C. Ospino, I. Herrera, R.P. (orcid)0000-0002-2315-9079 Marzo, I. Universidad de Zaragoza Laguna, A. Gimeno, M.C. 1002 050 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Biología Celular 48, 9 (2019), 3098-3108 Dalton Trans. Dalton Transactions 1477-9226 854971 http://zaguan.unizar.es/record/87700/files/texto_completo.pdf Postprint 68261 http://zaguan.unizar.es/record/87700/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:87700 articulos driver 2020-07-16-09:05:11 ARTICLE