000087704 001__ 87704
000087704 005__ 20210318091408.0
000087704 0247_ $$2doi$$a10.1111/aogs.13556
000087704 0248_ $$2sideral$$a111299
000087704 037__ $$aART-2019-111299
000087704 041__ $$aeng
000087704 100__ $$0(orcid)0000-0002-8218-1460$$aDe Bonrostro Torralba, C.$$uUniversidad de Zaragoza
000087704 245__ $$aLow dose vaginal misoprostol vs vaginal dinoprostone insert for induction of labor beyond 41st week: a randomized trial
000087704 260__ $$c2019
000087704 5060_ $$aAccess copy available to the general public$$fUnrestricted
000087704 5203_ $$aIntroduction: The aim of this study was to compare the efficacy and safety of a low‐dose protocol of vaginal misoprostol and vaginal dinoprostone insert for induction of labor in women with post‐term pregnancies. Material and methods: We designed a prospective, randomized, open‐labeled trial with evaluators blinded to the end‐point, including women of at least 41 weeks of gestational age with uncomplicated singleton pregnancies and a Bishop score <6. They were randomized into dinoprostone or misoprostol groups in a 1:1 ratio. Baseline maternal data and perinatal outcomes were recorded for statistical analysis. Successful vaginal delivery within 24 hours was the primary outcome variable. A P value <0.05 was considered statistically significant. This study was registered in ClinicalTrials.gov (number NTC03744364). Results: We included 198 women for analysis (99 women in each group). Vaginal birth rate within 24 hours did not differ between groups (49.5% vs 42.4%; P = 0.412). When the Bishop score was <4, dinoprostone insert showed a higher probability of vaginal delivery within 12 hours (17.8% vs 4%; P = 0.012). In the dinoprostone group, removal of the insert was more likely to be due to an adverse event (5.1% vs 14.1%; P = 0.051) and an abnormal fetal heart rate pattern during active labor (44.4% vs 58.6%; P = 0.047). Both groups were similar in neonatal outcomes including Apgar score, umbilical cord pH and neonatal intensive care unit admission. Conclusions: Low‐dose vaginal misoprostol and vaginal dinoprostone insert seem to be equally effective and safe for induction of labor in pregnant women with a gestational age beyond 41 weeks.
000087704 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000087704 590__ $$a2.77$$b2019
000087704 591__ $$aOBSTETRICS & GYNECOLOGY$$b23 / 82 = 0.28$$c2019$$dQ2$$eT1
000087704 592__ $$a1.254$$b2019
000087704 593__ $$aObstetrics and Gynecology$$c2019$$dQ1
000087704 593__ $$aMedicine (miscellaneous)$$c2019$$dQ1
000087704 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000087704 700__ $$aTejero Cabrejas, E.L.
000087704 700__ $$aEnvid Lázaro, B.M.
000087704 700__ $$aFranco Royo, M.J.
000087704 700__ $$aRoca Arquillué, M.
000087704 700__ $$0(orcid)0000-0002-0306-8858$$aCampillos Maza, J.M.$$uUniversidad de Zaragoza
000087704 7102_ $$11004$$2645$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Obstetricia y Ginecología
000087704 773__ $$g98, 7 (2019), 913-919$$pActa obstet. gynecol. Scand.$$tACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA$$x0001-6349
000087704 8564_ $$s174407$$uhttps://zaguan.unizar.es/record/87704/files/texto_completo.pdf$$yPostprint
000087704 8564_ $$s246673$$uhttps://zaguan.unizar.es/record/87704/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000087704 909CO $$ooai:zaguan.unizar.es:87704$$particulos$$pdriver
000087704 951__ $$a2021-03-18-09:09:56
000087704 980__ $$aARTICLE