000087708 001__ 87708
000087708 005__ 20220425105229.0
000087708 0247_ $$2doi$$a10.1002/chem.201806307
000087708 0248_ $$2sideral$$a110080
000087708 037__ $$aART-2019-110080
000087708 041__ $$aeng
000087708 100__ $$0(orcid)0000-0001-5835-1223$$aOrtega-Liebana, M.C.
000087708 245__ $$aUpconverting Carbon Nanodots from EDTA as Near-Infrared Activated Phototheranostic Agents
000087708 260__ $$c2019
000087708 5060_ $$aAccess copy available to the general public$$fUnrestricted
000087708 5203_ $$aThis work describes the synthesis of nitrogen-doped carbon nanodots (CNDs) synthesized from ethylene diamine tetra acetic acid (EDTA) as a precursor and their application as luminescent agents with a dual-mode theranostic role as near-infrared (NIR) triggered imaging and photodynamic therapy agents. Interestingly, these fluorescent CNDs are more rapidly and selectively internalized in tumor cells and exhibit no cytotoxicity until remotely activated with a NIR illumination source. These CNDs are excellent candidates for photo-theranostic purposes, i.e.: simultaneous imaging and therapy can be carried out on cancer cells using their luminescent properties and the in situ generation of reactive oxidative species (ROS) upon excitation in the NIR range. In the presence of CNDs NIR remote activation induces the in vitro killing of U251 MG cells. Through the use of flow imaging cytometry we have been able to successfully map and quantify the different type of cell deaths induced by the presence of intracellular superoxide anions (¿O2-) and hydrogen peroxide (H2O2) ROS species generated in situ upon NIR irradiation.
000087708 536__ $$9info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE$$9info:eu-repo/grantAgreement/EC/FP7/294094/EU/Synthesis and characterization of NANOstructured materials with LumInescent properties for diaGnostic and tHerapeuTic applications/NANOLIGHT$$9info:eu-repo/grantAgreement/EUR/ERC/HECTOR-267626$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCE
000087708 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000087708 590__ $$a4.857$$b2019
000087708 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b44 / 177 = 0.249$$c2019$$dQ1$$eT1
000087708 592__ $$a1.681$$b2019
000087708 593__ $$aCatalysis$$c2019$$dQ1
000087708 593__ $$aOrganic Chemistry$$c2019$$dQ1
000087708 593__ $$aChemistry (miscellaneous)$$c2019$$dQ1
000087708 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000087708 700__ $$0(orcid)0000-0003-4891-105X$$aEncabo-Berzosa, M.M.
000087708 700__ $$aCasanova, Á
000087708 700__ $$0(orcid)0000-0002-9357-143X$$aPereboom, M.D.$$uUniversidad de Zaragoza
000087708 700__ $$0(orcid)0000-0002-9813-8264$$aAlda, O.$$uUniversidad de Zaragoza
000087708 700__ $$0(orcid)0000-0002-4546-4111$$aHueso, J.L.
000087708 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaría, J.$$uUniversidad de Zaragoza
000087708 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología
000087708 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000087708 773__ $$g25, 21 (2019), 5539-5546$$pChemistry (Weinh.)$$tChemistry - A European Journal$$x0947-6539
000087708 8564_ $$s4004205$$uhttps://zaguan.unizar.es/record/87708/files/texto_completo.pdf$$yPostprint
000087708 8564_ $$s221294$$uhttps://zaguan.unizar.es/record/87708/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000087708 909CO $$ooai:zaguan.unizar.es:87708$$particulos$$pdriver
000087708 951__ $$a2022-04-25-10:35:26
000087708 980__ $$aARTICLE