87708 20220425105229.0 doi 10.1002/chem.201806307 sideral 110080 ART-2019-110080 eng Ortega-Liebana, M.C. (orcid)0000-0001-5835-1223 Upconverting Carbon Nanodots from EDTA as Near-Infrared Activated Phototheranostic Agents 2019 Access copy available to the general public Unrestricted This work describes the synthesis of nitrogen-doped carbon nanodots (CNDs) synthesized from ethylene diamine tetra acetic acid (EDTA) as a precursor and their application as luminescent agents with a dual-mode theranostic role as near-infrared (NIR) triggered imaging and photodynamic therapy agents. Interestingly, these fluorescent CNDs are more rapidly and selectively internalized in tumor cells and exhibit no cytotoxicity until remotely activated with a NIR illumination source. These CNDs are excellent candidates for photo-theranostic purposes, i.e.: simultaneous imaging and therapy can be carried out on cancer cells using their luminescent properties and the in situ generation of reactive oxidative species (ROS) upon excitation in the NIR range. In the presence of CNDs NIR remote activation induces the in vitro killing of U251 MG cells. Through the use of flow imaging cytometry we have been able to successfully map and quantify the different type of cell deaths induced by the presence of intracellular superoxide anions (¿O2-) and hydrogen peroxide (H2O2) ROS species generated in situ upon NIR irradiation. info:eu-repo/grantAgreement/EUR/ERC/HECTOR-267626 info:eu-repo/grantAgreement/EC/FP7/294094/EU/Synthesis and characterization of NANOstructured materials with LumInescent properties for diaGnostic and tHerapeuTic applications/NANOLIGHT info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCE info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 4.857 2019 CHEMISTRY, MULTIDISCIPLINARY 44 / 177 = 0.249 2019 Q1 T1 1.681 2019 Catalysis 2019 Q1 Organic Chemistry 2019 Q1 Chemistry (miscellaneous) 2019 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Encabo-Berzosa, M.M. (orcid)0000-0003-4891-105X Casanova, Á Pereboom, M.D. Universidad de Zaragoza (orcid)0000-0002-9357-143X Alda, O. Universidad de Zaragoza (orcid)0000-0002-9813-8264 Hueso, J.L. (orcid)0000-0002-4546-4111 Santamaría, J. Universidad de Zaragoza (orcid)0000-0002-8701-9745 1005 410 Universidad de Zaragoza Dpto. Farmacología y Fisiolog. Área Fisiología 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 25, 21 (2019), 5539-5546 Chemistry (Weinh.) Chemistry - A European Journal 0947-6539 4004205 http://zaguan.unizar.es/record/87708/files/texto_completo.pdf Postprint 221294 http://zaguan.unizar.es/record/87708/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:87708 articulos driver 2022-04-25-10:35:26 ARTICLE