000087828 001__ 87828
000087828 005__ 20230421130006.0
000087828 0247_ $$2doi$$a10.1016/j.jad.2019.02.050
000087828 0248_ $$2sideral$$a111180
000087828 037__ $$aART-2019-111180
000087828 041__ $$aeng
000087828 100__ $$0(orcid)0000-0002-7297-6104$$aSantabárbara, J.$$uUniversidad de Zaragoza
000087828 245__ $$aClinically relevant anxiety and risk of Alzheimer's disease in an elderly community sample: 4.5 years of follow-up.
000087828 260__ $$c2019
000087828 5060_ $$aAccess copy available to the general public$$fUnrestricted
000087828 5203_ $$aObjectives: To investigate whether clinically relevant anxiety increased the risk for developing Alzheimer''s disease (AD) while controlling for the presence of depression and other confounders; and to report the population attributable fraction (PAF) associated with anxiety disorder.
Method: We used data from the longitudinal, community-based Zaragoza Dementia and Depression (ZARADEMP) study. A random sample of 4057 dementia-free community dwellers aged =55 years were followed for 4.5 years. The Geriatric Mental State-Automated Geriatric Examination for Computer Assisted Taxonomy package was used for the diagnosis of clinically significant cases and subcases of anxiety; and AD was diagnosed by a panel of research psychiatrists according to DSM-IV criteria. Multivariate survival analysis with competing risk regression model was performed.
Results: We observed a significant association between anxiety cases at baseline and AD risk in the univariate analysis that persisted in the fully adjusted model (SHR: 3.90; 95% CI: 1.59–9.60; p = 0.003), with a PAF for AD of 6.11% (95% CI: 1.30%–16.17%). No significant association between ‘subcases’ of anxiety at baseline and AD risk was found.
Limitations: Data on apolipoprotein E were not available. The hospital-based diagnosis was not completed in all cases of dementia.
Conclusion: Late-life, clinically significant anxiety (but not subclinical anxiety) seems to increase the risk of AD, independently of the effect of several confounders, including depression. Taking into account the high prevalence of anxiety among the elderly, future studies are warranted to determine potential risk reduction of AD.
000087828 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000087828 590__ $$a3.892$$b2019
000087828 592__ $$a1.945$$b2019
000087828 591__ $$aCLINICAL NEUROLOGY$$b50 / 204 = 0.245$$c2019$$dQ1$$eT1
000087828 593__ $$aPsychiatry and Mental Health$$c2019$$dQ1
000087828 591__ $$aPSYCHIATRY$$b25 / 140 = 0.179$$c2019$$dQ1$$eT1
000087828 593__ $$aClinical Psychology$$c2019$$dQ1
000087828 591__ $$aPSYCHIATRY$$b39 / 154 = 0.253$$c2019$$dQ2$$eT1
000087828 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000087828 700__ $$aVillagrasa, B.
000087828 700__ $$0(orcid)0000-0002-3360-7015$$aLópez-Antón, R.$$uUniversidad de Zaragoza
000087828 700__ $$aOlaya, B.
000087828 700__ $$aBueno-Notivol, J.
000087828 700__ $$0(orcid)0000-0003-2284-7862$$ade la Cámara, C.$$uUniversidad de Zaragoza
000087828 700__ $$0(orcid)0000-0001-9822-6312$$aGracia-García, P.$$uUniversidad de Zaragoza
000087828 700__ $$0(orcid)0000-0002-1252-2397$$aLobo, E.$$uUniversidad de Zaragoza
000087828 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, A.$$uUniversidad de Zaragoza
000087828 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica
000087828 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000087828 7102_ $$11008$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Medic.Prevent.Salud Públ.
000087828 773__ $$g250 (2019), 16-20$$pJ. affect. disord.$$tJournal of Affective Disorders$$x0165-0327
000087828 8564_ $$s349990$$uhttps://zaguan.unizar.es/record/87828/files/texto_completo.pdf$$yPostprint
000087828 8564_ $$s58671$$uhttps://zaguan.unizar.es/record/87828/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
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000087828 951__ $$a2023-04-21-12:39:56
000087828 980__ $$aARTICLE