87828 20230421130006.0 doi 10.1016/j.jad.2019.02.050 sideral 111180 ART-2019-111180 eng Santabárbara, J. Universidad de Zaragoza (orcid)0000-0002-7297-6104 Clinically relevant anxiety and risk of Alzheimer's disease in an elderly community sample: 4.5 years of follow-up. 2019 Access copy available to the general public Unrestricted Objectives: To investigate whether clinically relevant anxiety increased the risk for developing Alzheimer''s disease (AD) while controlling for the presence of depression and other confounders; and to report the population attributable fraction (PAF) associated with anxiety disorder. Method: We used data from the longitudinal, community-based Zaragoza Dementia and Depression (ZARADEMP) study. A random sample of 4057 dementia-free community dwellers aged =55 years were followed for 4.5 years. The Geriatric Mental State-Automated Geriatric Examination for Computer Assisted Taxonomy package was used for the diagnosis of clinically significant cases and subcases of anxiety; and AD was diagnosed by a panel of research psychiatrists according to DSM-IV criteria. Multivariate survival analysis with competing risk regression model was performed. Results: We observed a significant association between anxiety cases at baseline and AD risk in the univariate analysis that persisted in the fully adjusted model (SHR: 3.90; 95% CI: 1.59–9.60; p = 0.003), with a PAF for AD of 6.11% (95% CI: 1.30%–16.17%). No significant association between ‘subcases’ of anxiety at baseline and AD risk was found. Limitations: Data on apolipoprotein E were not available. The hospital-based diagnosis was not completed in all cases of dementia. Conclusion: Late-life, clinically significant anxiety (but not subclinical anxiety) seems to increase the risk of AD, independently of the effect of several confounders, including depression. Taking into account the high prevalence of anxiety among the elderly, future studies are warranted to determine potential risk reduction of AD. info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.892 2019 CLINICAL NEUROLOGY 50 / 204 = 0.245 2019 Q1 T1 PSYCHIATRY 25 / 140 = 0.179 2019 Q1 T1 PSYCHIATRY 39 / 154 = 0.253 2019 Q2 T1 1.945 2019 Psychiatry and Mental Health 2019 Q1 Clinical Psychology 2019 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Villagrasa, B. López-Antón, R. Universidad de Zaragoza (orcid)0000-0002-3360-7015 Olaya, B. Bueno-Notivol, J. de la Cámara, C. Universidad de Zaragoza (orcid)0000-0003-2284-7862 Gracia-García, P. Universidad de Zaragoza (orcid)0000-0001-9822-6312 Lobo, E. Universidad de Zaragoza (orcid)0000-0002-1252-2397 Lobo, A. Universidad de Zaragoza (orcid)0000-0002-9098-655X 4009 730 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicología Básica 1007 745 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Psiquiatría 1008 615 Universidad de Zaragoza Dpto. Microb.Med.Pr.,Sal.Públ. Área Medic.Prevent.Salud Públ. 250 (2019), 16-20 J. affect. disord. Journal of Affective Disorders 0165-0327 349990 http://zaguan.unizar.es/record/87828/files/texto_completo.pdf Postprint 58671 http://zaguan.unizar.es/record/87828/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:87828 articulos driver 2023-04-21-12:39:56 ARTICLE