000087829 001__ 87829 000087829 005__ 20200716101425.0 000087829 0247_ $$2doi$$a10.1016/j.diabres.2019.02.017 000087829 0248_ $$2sideral$$a111194 000087829 037__ $$aART-2019-111194 000087829 041__ $$aeng 000087829 100__ $$aMavrogianni, C. 000087829 245__ $$aEvaluation of the Finnish Diabetes Risk Score as a screening tool for undiagnosed type 2 diabetes and dysglycaemia among early middle-aged adults in a large-scale European cohort. The Feel4Diabetes-study 000087829 260__ $$c2019 000087829 5060_ $$aAccess copy available to the general public$$fUnrestricted 000087829 5203_ $$aAim: To assess the diagnostic accuracy of the FINDRISC for undiagnosed type 2 diabetes mellitus (T2DM) and dysglycaemia (i.e. the presence of prediabetes or T2DM) among early middle-aged adults from vulnerable groups in a large-scale European cohort. Methods: Participants were recruited from low-socioeconomic areas in high-income countries (HICs) (Belgium-Finland) and in HICs under austerity measures (Greece-Spain) and from the overall population in low/middle-income countries (LMICs) (Bulgaria-Hungary). Study population comprised of 2116 parents of primary-school children from families identified at increased risk of T2DM, based on parental self-reported FINDRISC. Sensitivity (Se), specificity (Sp), area under the receiver operating characteristic curves (AUC-ROC) and the optimal cut-offs of FINDRISC that indicate an increased probability for undiagnosed T2DM or dysglycaemia were calculated. Results: The AUC-ROC for undiagnosed T2DM was 0.824 with optimal cut-off =14 (Se = 68%, Sp = 81.7%) for the total sample, 0.839 with optimal cut-off =15 (Se = 83.3%, Sp = 86.9%) for HICs, 0.794 with optimal cut-off =12 (Se = 83.3%, Sp = 61.1%) for HICs under austerity measures and 0.882 with optimal cut-off =14 (Se = 71.4%, Sp = 87.8%) for LMICs. The AUC-ROC for dysglycaemia was 0.663 with optimal cut-off =12 (Se = 58.3%, Sp = 65.7%) for the total sample, 0.656 with optimal cut-off =12 (Se = 54.5%, Sp = 64.8%) for HICs, 0.631 with optimal cut-off =12 (Se = 59.7%, Sp = 62.0%) for HICs under austerity measures and 0.735 with optimal cut-off =11 (Se = 72.7%, Sp = 70.2%) for LMICs. Conclusion: FINDRISC can be applied for screening primarily undiagnosed T2DM but also dysglycaemia among vulnerable groups across Europe, considering the use of different cut-offs for each subpopulation. 000087829 536__ $$9info:eu-repo/grantAgreement/EC/H2020/643708/EU/Developing and implementing a community-based intervention to create a more supportive social and physical environment for lifestyle changes to prevent diabetes in vulnerable families across Europe/Feel4Diabetes$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 643708-Feel4Diabetes 000087829 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000087829 590__ $$a4.234$$b2019 000087829 592__ $$a1.402$$b2019 000087829 591__ $$aENDOCRINOLOGY & METABOLISM$$b34 / 143 = 0.238$$c2019$$dQ1$$eT1 000087829 593__ $$aEndocrinology$$c2019$$dQ1 000087829 593__ $$aMedicine (miscellaneous)$$c2019$$dQ1 000087829 593__ $$aInternal Medicine$$c2019$$dQ1 000087829 593__ $$aEndocrinology, Diabetes and Metabolism$$c2019$$dQ1 000087829 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000087829 700__ $$aLambrinou, C.P. 000087829 700__ $$aAndroutsos, O. 000087829 700__ $$aLindström, J. 000087829 700__ $$aKivelä, J. 000087829 700__ $$aCardon, G. 000087829 700__ $$aHuys, N. 000087829 700__ $$aTsochev, K. 000087829 700__ $$aIotova, V. 000087829 700__ $$aChakarova, N. 000087829 700__ $$aRurik, I. 000087829 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, L.A.$$uUniversidad de Zaragoza 000087829 700__ $$aLiatis, S. 000087829 700__ $$aMakrilakis, K. 000087829 700__ $$aManios, Y. 000087829 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería 000087829 773__ $$g150 (2019), 99-110$$pDiabetes res. clin. pract.$$tDIABETES RESEARCH AND CLINICAL PRACTICE$$x0168-8227 000087829 8564_ $$s837786$$uhttps://zaguan.unizar.es/record/87829/files/texto_completo.pdf$$yPostprint 000087829 8564_ $$s299455$$uhttps://zaguan.unizar.es/record/87829/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000087829 909CO $$ooai:zaguan.unizar.es:87829$$particulos$$pdriver 000087829 951__ $$a2020-07-16-08:44:14 000087829 980__ $$aARTICLE