87829 20200716101425.0 doi 10.1016/j.diabres.2019.02.017 sideral 111194 ART-2019-111194 eng Mavrogianni, C. Evaluation of the Finnish Diabetes Risk Score as a screening tool for undiagnosed type 2 diabetes and dysglycaemia among early middle-aged adults in a large-scale European cohort. The Feel4Diabetes-study 2019 Access copy available to the general public Unrestricted Aim: To assess the diagnostic accuracy of the FINDRISC for undiagnosed type 2 diabetes mellitus (T2DM) and dysglycaemia (i.e. the presence of prediabetes or T2DM) among early middle-aged adults from vulnerable groups in a large-scale European cohort. Methods: Participants were recruited from low-socioeconomic areas in high-income countries (HICs) (Belgium-Finland) and in HICs under austerity measures (Greece-Spain) and from the overall population in low/middle-income countries (LMICs) (Bulgaria-Hungary). Study population comprised of 2116 parents of primary-school children from families identified at increased risk of T2DM, based on parental self-reported FINDRISC. Sensitivity (Se), specificity (Sp), area under the receiver operating characteristic curves (AUC-ROC) and the optimal cut-offs of FINDRISC that indicate an increased probability for undiagnosed T2DM or dysglycaemia were calculated. Results: The AUC-ROC for undiagnosed T2DM was 0.824 with optimal cut-off =14 (Se = 68%, Sp = 81.7%) for the total sample, 0.839 with optimal cut-off =15 (Se = 83.3%, Sp = 86.9%) for HICs, 0.794 with optimal cut-off =12 (Se = 83.3%, Sp = 61.1%) for HICs under austerity measures and 0.882 with optimal cut-off =14 (Se = 71.4%, Sp = 87.8%) for LMICs. The AUC-ROC for dysglycaemia was 0.663 with optimal cut-off =12 (Se = 58.3%, Sp = 65.7%) for the total sample, 0.656 with optimal cut-off =12 (Se = 54.5%, Sp = 64.8%) for HICs, 0.631 with optimal cut-off =12 (Se = 59.7%, Sp = 62.0%) for HICs under austerity measures and 0.735 with optimal cut-off =11 (Se = 72.7%, Sp = 70.2%) for LMICs. Conclusion: FINDRISC can be applied for screening primarily undiagnosed T2DM but also dysglycaemia among vulnerable groups across Europe, considering the use of different cut-offs for each subpopulation. info:eu-repo/grantAgreement/EC/H2020/643708/EU/Developing and implementing a community-based intervention to create a more supportive social and physical environment for lifestyle changes to prevent diabetes in vulnerable families across Europe/Feel4Diabetes This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 643708-Feel4Diabetes info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 4.234 2019 1.402 2019 ENDOCRINOLOGY & METABOLISM 34 / 143 = 0.238 2019 Q1 T1 Endocrinology 2019 Q1 Medicine (miscellaneous) 2019 Q1 Internal Medicine 2019 Q1 Endocrinology, Diabetes and Metabolism 2019 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Lambrinou, C.P. Androutsos, O. Lindström, J. Kivelä, J. Cardon, G. Huys, N. Tsochev, K. Iotova, V. Chakarova, N. Rurik, I. (orcid)0000-0003-0454-653X Moreno, L.A. Universidad de Zaragoza Liatis, S. Makrilakis, K. Manios, Y. 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 150 (2019), 99-110 Diabetes res. clin. pract. DIABETES RESEARCH AND CLINICAL PRACTICE 0168-8227 837786 http://zaguan.unizar.es/record/87829/files/texto_completo.pdf Postprint 299455 http://zaguan.unizar.es/record/87829/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:87829 articulos driver 2020-07-16-08:44:14 ARTICLE