Natural Polysaccharides for siRNA Delivery: Nanocarriers Based on Chitosan, Hyaluronic Acid, and Their Derivatives
Serrano-Sevilla, Inés ; Artiga, Álvaro ; Mitchell, G. Scott ; De Matteis, Laura ; de la Fuente, M. Jesús
Resumen: Natural polysaccharides are frequently used in the design of drug delivery systems due to their biocompatibility, biodegradability, and low toxicity. Moreover, they are diverse in structure, size, and charge, and their chemical functional groups can be easily modified to match the needs of the final application and mode of administration. This review focuses on polysaccharidic nanocarriers based on chitosan and hyaluronic acid for small interfering RNA (siRNA) delivery, which are highly positively and negatively charged, respectively. The key properties, strengths, and drawbacks of each polysaccharide are discussed. In addition, their use as efficient nanodelivery systems for gene silencing applications is put into context using the most recent examples from the literature. The latest advances in this field illustrate effectively how chitosan and hyaluronic acid can be modified or associated with other molecules in order to overcome their limitations to produce optimized siRNA delivery systems with promising in vitro and in vivo results
Idioma: Inglés
DOI: 10.3390/molecules24142570
Año: 2019
Publicado en: Molecules 24, 14 (2019), 2570 [34 pp.]
ISSN: 1420-3049
Factor impacto JCR: 3.267 (2019)
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 70 / 177 = 0.395 (2019) - Q2 - T2
Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 141 / 297 = 0.475 (2019) - Q2 - T2
Factor impacto SCIMAGO: 0.698 - Pharmaceutical Science (Q1) - Chemistry (miscellaneous) (Q2) - Drug Discovery (Q2) - Physical and Theoretical Chemistry (Q2) - Organic Chemistry (Q2) - Analytical Chemistry (Q2) - Medicine (miscellaneous) (Q2) - Molecular Medicine (Q3)
Financiación: info:eu-repo/grantAgreement/ES/MINECO/FPI-BES-2015-071304
Financiación: info:eu-repo/grantAgreement/ES/MEC/FPU014-06249
Financiación: info:eu-repo/grantAgreement/ES/MINECO/SAF2014-54763-C2-2-R
Tipo y forma: Article (Published version)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
Exportado de SIDERAL (2020-07-16-09:52:25)
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Idioma: Inglés
DOI: 10.3390/molecules24142570
Año: 2019
Publicado en: Molecules 24, 14 (2019), 2570 [34 pp.]
ISSN: 1420-3049
Factor impacto JCR: 3.267 (2019)
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 70 / 177 = 0.395 (2019) - Q2 - T2
Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 141 / 297 = 0.475 (2019) - Q2 - T2
Factor impacto SCIMAGO: 0.698 - Pharmaceutical Science (Q1) - Chemistry (miscellaneous) (Q2) - Drug Discovery (Q2) - Physical and Theoretical Chemistry (Q2) - Organic Chemistry (Q2) - Analytical Chemistry (Q2) - Medicine (miscellaneous) (Q2) - Molecular Medicine (Q3)
Financiación: info:eu-repo/grantAgreement/ES/MINECO/FPI-BES-2015-071304
Financiación: info:eu-repo/grantAgreement/ES/MEC/FPU014-06249
Financiación: info:eu-repo/grantAgreement/ES/MINECO/SAF2014-54763-C2-2-R
Tipo y forma: Article (Published version)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. Exportado de SIDERAL (2020-07-16-09:52:25)
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Record created 2020-02-21, last modified 2020-07-16