Silver(I) and copper(I) complexes with a Schiff base derived from 2-aminofluorene with promising antibacterial activity

Cifuentes-Vaca, O.L. ; Andrades-Lagos, J. ; Campanini-Salinas, J. ; Laguna, A. (Universidad de Zaragoza) ; Vásquez-Velásquez, D. ; Concepción Gimeno, M. (Universidad de Zaragoza)

Resumen: By reaction of 2-aminofluorene with 2-pyridinecarboxaldehyde a new Schiff base (L) is obtained. The reaction of this ligand with Ag(I) and Cu(I) salts in different stoichiometry leads to the complexes [Ag(CF 3 SO 3 )(L)PPh 3 ] (1) or [ML 2 ]A (M = Ag, Cu; A = CF 3 SO 3 , ClO 4 or BF 4 ). Structural characterization by X-ray crystallography has been carried out for complexes [AgL 2 ]ClO 4 (4) and [Ag(L)(PPh 3 ) 2 ](CF 3 SO 3 ) (6), which confirms the chelate nature of L and the presence of Ag¿H interactions between two molecules. The biological studies show that Schiff base L presents antibacterial activity in Gram-positive bacteria and E. coli. The coordination to silver increases this activity, but the formation of the copper complex does not generate significant changes.

Idioma: Inglés

DOI: 10.1016/j.ica.2019.02.033

Año: 2019

Publicado en: INORGANICA CHIMICA ACTA 489 (2019), 275-279
ISSN: 0020-1693

Factor impacto JCR: 2.304 (2019)

Categ. JCR: CHEMISTRY, INORGANIC & NUCLEAR rank: 20 / 45 = 0.444 (2019) - Q2 - T2

Factor impacto SCIMAGO: 0.447 - Materials Chemistry (Q2) - Physical and Theoretical Chemistry (Q3) - Inorganic Chemistry (Q3)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/E07-17R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/CTQ2016-75816-C2-1-P

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Química Inorgánica (Dpto. Química Inorgánica)