000088189 001__ 88189
000088189 005__ 20210820090343.0
000088189 0247_ $$2doi$$a10.1016/j.bbr.2019.03.011
000088189 0248_ $$2sideral$$a111163
000088189 037__ $$aART-2019-111163
000088189 041__ $$aeng
000088189 100__ $$aZorzo, C.
000088189 245__ $$aAdult social isolation leads to anxiety and spatial memory impairment: Brain activity pattern of COx and c-Fos
000088189 260__ $$c2019
000088189 5060_ $$aAccess copy available to the general public$$fUnrestricted
000088189 5203_ $$aSocial isolation during adulthood is a frequent problem that leads to a large variety of adverse emotional and cognitive effects. However, most of the social isolation rodent procedures begin the separation early post-weaning. This work explores locomotor activity, anxiety-like behaviour, and spatial working memory after twelve weeks of adult social isolation. In order to study the functional contribution of selected brain areas following a working memory task, we assessed neuronal metabolic activity through quantitative cytochrome oxidase histochemistry and c-Fos immunohistochemistry. Behaviourally, we found that isolated animals (IS) showed anxiety-like behaviour and worse working memory than controls, whereas motor functions were preserved. Moreover, IS rats showed lower levels of learning-related c-Fos immunoreactivity, compared to controls, in the medial prefrontal cortex (mPFC), ventral tegmental area (VTA), and nucleus accumbens shell. In addition, the IS group showed lower neuronal metabolic activity in the mPFC, VTA, and CA1 subfield of the hippocampus. These results indicate that twelve weeks of social isolation in adult rats leads to different behavioural and brain alterations, and they highlight the importance of social support, not only in development, but also in adulthood.
000088189 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón$$9info:eu-repo/grantAgreement/ES/MINECO/PSI2015-73111-EXP$$9info:eu-repo/grantAgreement/ES/MINECO/PSI2017-83893-R$$9info:eu-repo/grantAgreement/ES/MINECO/PSI2017-90806-REDT
000088189 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000088189 590__ $$a2.977$$b2019
000088189 592__ $$a1.179$$b2019
000088189 591__ $$aBEHAVIORAL SCIENCES$$b14 / 52 = 0.269$$c2019$$dQ2$$eT1
000088189 593__ $$aBehavioral Neuroscience$$c2019$$dQ1
000088189 591__ $$aNEUROSCIENCES$$b143 / 271 = 0.528$$c2019$$dQ3$$eT2
000088189 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000088189 700__ $$0(orcid)0000-0002-4249-602X$$aMéndez-López, M.$$uUniversidad de Zaragoza
000088189 700__ $$aMéndez, M.
000088189 700__ $$aArias, J.L.
000088189 7102_ $$14009$$2725$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicobiología
000088189 773__ $$g365 (2019), 170-177$$pBehav. brain res.$$tBehavioural brain research$$x0166-4328
000088189 8564_ $$s514314$$uhttps://zaguan.unizar.es/record/88189/files/texto_completo.pdf$$yPostprint
000088189 8564_ $$s188009$$uhttps://zaguan.unizar.es/record/88189/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000088189 909CO $$ooai:zaguan.unizar.es:88189$$particulos$$pdriver
000088189 951__ $$a2021-08-20-08:36:09
000088189 980__ $$aARTICLE