88189 20210820090343.0 doi 10.1016/j.bbr.2019.03.011 sideral 111163 ART-2019-111163 eng Zorzo, C. Adult social isolation leads to anxiety and spatial memory impairment: Brain activity pattern of COx and c-Fos 2019 Access copy available to the general public Unrestricted Social isolation during adulthood is a frequent problem that leads to a large variety of adverse emotional and cognitive effects. However, most of the social isolation rodent procedures begin the separation early post-weaning. This work explores locomotor activity, anxiety-like behaviour, and spatial working memory after twelve weeks of adult social isolation. In order to study the functional contribution of selected brain areas following a working memory task, we assessed neuronal metabolic activity through quantitative cytochrome oxidase histochemistry and c-Fos immunohistochemistry. Behaviourally, we found that isolated animals (IS) showed anxiety-like behaviour and worse working memory than controls, whereas motor functions were preserved. Moreover, IS rats showed lower levels of learning-related c-Fos immunoreactivity, compared to controls, in the medial prefrontal cortex (mPFC), ventral tegmental area (VTA), and nucleus accumbens shell. In addition, the IS group showed lower neuronal metabolic activity in the mPFC, VTA, and CA1 subfield of the hippocampus. These results indicate that twelve weeks of social isolation in adult rats leads to different behavioural and brain alterations, and they highlight the importance of social support, not only in development, but also in adulthood. info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón info:eu-repo/grantAgreement/ES/MINECO/PSI2015-73111-EXP info:eu-repo/grantAgreement/ES/MINECO/PSI2017-83893-R info:eu-repo/grantAgreement/ES/MINECO/PSI2017-90806-REDT info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 2.977 2019 BEHAVIORAL SCIENCES 14 / 52 = 0.269 2019 Q2 T1 NEUROSCIENCES 143 / 271 = 0.528 2019 Q3 T2 1.179 2019 Behavioral Neuroscience 2019 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Méndez-López, M. Universidad de Zaragoza (orcid)0000-0002-4249-602X Méndez, M. Arias, J.L. 4009 725 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicobiología 365 (2019), 170-177 Behav. brain res. Behavioural brain research 0166-4328 514314 http://zaguan.unizar.es/record/88189/files/texto_completo.pdf Postprint 188009 http://zaguan.unizar.es/record/88189/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:88189 articulos driver 2021-08-20-08:36:09 ARTICLE