000088201 001__ 88201
000088201 005__ 20240125154836.0
000088201 0247_ $$2doi$$a10.1016/j.clnu.2019.02.025
000088201 0248_ $$2sideral$$a111242
000088201 037__ $$aART-2020-111242
000088201 041__ $$aeng
000088201 100__ $$0(orcid)0000-0001-6650-8294$$aMateo-Gallego, R.$$uUniversidad de Zaragoza
000088201 245__ $$aEffect of an alcohol-free beer enriched with isomaltulose and a resistant dextrin on insulin resistance in diabetic patients with overweight or obesity
000088201 260__ $$c2020
000088201 5060_ $$aAccess copy available to the general public$$fUnrestricted
000088201 5203_ $$aBackground & aims: The quality of carbohydrates has an essential role in nutritional management of type 2 diabetes mellitus (T2DM) because of its substantial impact on glucose homeostasis. Alcohol-free beer has beneficial bioactive components but it has a relatively high glycemic-index so its consumption is restricted in diabetic subjects. We aimed to explore the effect of an alcohol-free beer with modified carbohydrate composition almost completely eliminating maltose and adding isomaltulose (16.5 g/day) and a resistant maltodextrin (5.28 g/day) in comparison to a regular alcohol-free beer on glycemic control of diabetic subjects with overweight or obesity. Design: We randomized 41 subjects into two groups: a) consumption of 66 cL/day of; regular alcohol-free beer for the first 10 weeks and 66 cL/day of alcohol-free beer with modified carbohydrate composition for the next 10 weeks; b) the same described intervention in opposite order. There was a washout period for 6–8 weeks between the two interventions. Participants were counseled to adhere to a healthy diet for cardiovascular health and to increase physical activity. Clinical, biochemical, anthropometric, lifestyle and satiety assessments were performed at the beginning and at the end of each period. Results: Subjects showed significantly weight loss after the two ten weeks periods (-1.69 ± 3.21% and -1.77 ± 3.70% after experimental and regular alcohol-free beers, respectively, P = 0.881). Glucose and glycated hemoglobin did not significantly change after any period. Insulin concentrations and HOMA-IR significantly decreased (-11.1 [–21.3-4.64]% and -1.92 ± 32.8% respectively) after the intake of experimental alcohol-free beer but not after regular alcohol-free beer. Reductions remained statistically significant after adjusting for weight loss, energy intake, physical activity and intervention order. Subjects reported higher satiety scores after consuming experimental alcohol-free beer. Conclusions: An alcohol-free beer including the substitution of regular carbohydrates for low doses of isomaltulose and the addition of a resistant maltodextrin within meals led to an improvement in insulin resistance in subjects with T2DM and overweight or obesity. Clinical trial registration: The clinical trial has been registered in ClinicalTrials.gov (Identifier: NCT03337828).
000088201 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-00114
000088201 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000088201 590__ $$a7.324$$b2020
000088201 591__ $$aNUTRITION & DIETETICS$$b7 / 87 = 0.08$$c2020$$dQ1$$eT1
000088201 592__ $$a1.915$$b2020
000088201 593__ $$aNutrition and Dietetics$$c2020$$dQ1
000088201 593__ $$aCritical Care and Intensive Care Medicine$$c2020$$dQ1
000088201 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000088201 700__ $$0(orcid)0000-0002-1894-1621$$aPérez-Calahorra, S.$$uUniversidad de Zaragoza
000088201 700__ $$0(orcid)0000-0002-9647-0108$$aLamiquiz-Moneo, I.
000088201 700__ $$aMarco-Benedí, V.$$uUniversidad de Zaragoza
000088201 700__ $$aBea, A.M.
000088201 700__ $$0(orcid)0000-0002-9337-6837$$aFumanal, A.J.
000088201 700__ $$aPrieto-Martín, A.
000088201 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, M.$$uUniversidad de Zaragoza
000088201 700__ $$aCenarro, A.
000088201 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, F.$$uUniversidad de Zaragoza
000088201 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000088201 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000088201 773__ $$g39, 2 (2020), 475-483$$pClin. nutr.$$tClinical Nutrition$$x0261-5614
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000088201 951__ $$a2024-01-25-15:08:21
000088201 980__ $$aARTICLE