88201 20240125154836.0 doi 10.1016/j.clnu.2019.02.025 sideral 111242 ART-2020-111242 eng Mateo-Gallego, R. Universidad de Zaragoza (orcid)0000-0001-6650-8294 Effect of an alcohol-free beer enriched with isomaltulose and a resistant dextrin on insulin resistance in diabetic patients with overweight or obesity 2020 Access copy available to the general public Unrestricted Background & aims: The quality of carbohydrates has an essential role in nutritional management of type 2 diabetes mellitus (T2DM) because of its substantial impact on glucose homeostasis. Alcohol-free beer has beneficial bioactive components but it has a relatively high glycemic-index so its consumption is restricted in diabetic subjects. We aimed to explore the effect of an alcohol-free beer with modified carbohydrate composition almost completely eliminating maltose and adding isomaltulose (16.5 g/day) and a resistant maltodextrin (5.28 g/day) in comparison to a regular alcohol-free beer on glycemic control of diabetic subjects with overweight or obesity. Design: We randomized 41 subjects into two groups: a) consumption of 66 cL/day of; regular alcohol-free beer for the first 10 weeks and 66 cL/day of alcohol-free beer with modified carbohydrate composition for the next 10 weeks; b) the same described intervention in opposite order. There was a washout period for 6–8 weeks between the two interventions. Participants were counseled to adhere to a healthy diet for cardiovascular health and to increase physical activity. Clinical, biochemical, anthropometric, lifestyle and satiety assessments were performed at the beginning and at the end of each period. Results: Subjects showed significantly weight loss after the two ten weeks periods (-1.69 ± 3.21% and -1.77 ± 3.70% after experimental and regular alcohol-free beers, respectively, P = 0.881). Glucose and glycated hemoglobin did not significantly change after any period. Insulin concentrations and HOMA-IR significantly decreased (-11.1 [–21.3-4.64]% and -1.92 ± 32.8% respectively) after the intake of experimental alcohol-free beer but not after regular alcohol-free beer. Reductions remained statistically significant after adjusting for weight loss, energy intake, physical activity and intervention order. Subjects reported higher satiety scores after consuming experimental alcohol-free beer. Conclusions: An alcohol-free beer including the substitution of regular carbohydrates for low doses of isomaltulose and the addition of a resistant maltodextrin within meals led to an improvement in insulin resistance in subjects with T2DM and overweight or obesity. Clinical trial registration: The clinical trial has been registered in ClinicalTrials.gov (Identifier: NCT03337828). info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-00114 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 7.324 2020 NUTRITION & DIETETICS 7 / 87 = 0.08 2020 Q1 T1 1.915 2020 Nutrition and Dietetics 2020 Q1 Critical Care and Intensive Care Medicine 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Pérez-Calahorra, S. Universidad de Zaragoza (orcid)0000-0002-1894-1621 Lamiquiz-Moneo, I. (orcid)0000-0002-9647-0108 Marco-Benedí, V. Universidad de Zaragoza Bea, A.M. Fumanal, A.J. (orcid)0000-0002-9337-6837 Prieto-Martín, A. Laclaustra, M. Universidad de Zaragoza (orcid)0000-0003-3963-0846 Cenarro, A. Civeira, F. Universidad de Zaragoza (orcid)0000-0001-7043-0952 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 39, 2 (2020), 475-483 Clin. nutr. Clinical Nutrition 0261-5614 251807 http://zaguan.unizar.es/record/88201/files/texto_completo.pdf Postprint 44441 http://zaguan.unizar.es/record/88201/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:88201 articulos driver 2024-01-25-15:08:21 ARTICLE