000088215 001__ 88215
000088215 005__ 20200716101448.0
000088215 0247_ $$2doi$$a10.1021/acs.est.9b00373
000088215 0248_ $$2sideral$$a111458
000088215 037__ $$aART-2019-111458
000088215 041__ $$aeng
000088215 100__ $$aAllocca, M.
000088215 245__ $$aAn Integrated Multilevel Analysis Profiling Biosafety and Toxicity Induced by Indium- and Cadmium-Based Quantum Dots in Vivo
000088215 260__ $$c2019
000088215 5060_ $$aAccess copy available to the general public$$fUnrestricted
000088215 5203_ $$aIndium phosphide quantum dots (QDs) have emerged as a new class of fluorescent nanocrystals for manifold applications, from biophotonics to nanomedicine. Recent efforts in improving the photoluminescence quantum yield, the chemical stability and the biocompatibility turned them into a valid alternative to well established Cd-based nanocrystals. In vitro studies provided first evidence for the lower toxicity of In-based QDs. Nonetheless, an urgent need exists for further assessment of the potential toxic effects in vivo. Here we use the freshwater polyp Hydra vulgaris, a well-established model previously adopted to assess the toxicity of CdSe/CdS nanorods and CdTe QDs. A systematic multilevel analysis was carried out in vivo, ex vivo, and in vitro comparing toxicity end points of CdSe- and InP-based QDs, passivated by ZnSe/ZnS shells and surface functionalized with penicillamine. Final results demonstrate that both the chemical composition of the QD core (InP vs CdSe) and the shell play a crucial role for final outcomes. Remarkably, in absence of in vivo alterations, cell and molecular alterations revealed hidden toxicity aspects, highlighting the biosafety of InP-based nanocrystals and outlining the importance of integrated multilevel analyses for proper QDs risk assessment.
000088215 536__ $$9info:eu-repo/grantAgreement/EC/H2020/660228/EU/Profiling gene expression in Hydra vulgaris following Gold Nanoparticle-mediated hyperthermia/HyHeat$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 660228-HyHeat
000088215 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000088215 590__ $$a7.864$$b2019
000088215 591__ $$aENVIRONMENTAL SCIENCES$$b15 / 265 = 0.057$$c2019$$dQ1$$eT1
000088215 591__ $$aENGINEERING, ENVIRONMENTAL$$b6 / 53 = 0.113$$c2019$$dQ1$$eT1
000088215 592__ $$a2.704$$b2019
000088215 593__ $$aChemistry (miscellaneous)$$c2019$$dQ1
000088215 593__ $$aMedicine (miscellaneous)$$c2019$$dQ1
000088215 593__ $$aEnvironmental Chemistry$$c2019$$dQ1
000088215 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000088215 700__ $$aMattera, L.
000088215 700__ $$aBauduin, A.
000088215 700__ $$aMiedziak, B.
000088215 700__ $$0(orcid)0000-0002-2861-2469$$aMoros, M.$$uUniversidad de Zaragoza
000088215 700__ $$aDe Trizio, L.
000088215 700__ $$aTino, A.
000088215 700__ $$aReiss, P.
000088215 700__ $$aAmbrosone, A.
000088215 700__ $$aTortiglione, C.
000088215 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000088215 773__ $$g53, 7 (2019), 3938-3947$$pEnviron. sci. technol.$$tENVIRONMENTAL SCIENCE & TECHNOLOGY$$x0013-936X
000088215 8564_ $$s684380$$uhttps://zaguan.unizar.es/record/88215/files/texto_completo.pdf$$yPostprint
000088215 8564_ $$s316158$$uhttps://zaguan.unizar.es/record/88215/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000088215 909CO $$ooai:zaguan.unizar.es:88215$$particulos$$pdriver
000088215 951__ $$a2020-07-16-09:04:48
000088215 980__ $$aARTICLE