88215 20200716101448.0 doi 10.1021/acs.est.9b00373 sideral 111458 ART-2019-111458 eng Allocca, M. An Integrated Multilevel Analysis Profiling Biosafety and Toxicity Induced by Indium- and Cadmium-Based Quantum Dots in Vivo 2019 Access copy available to the general public Unrestricted Indium phosphide quantum dots (QDs) have emerged as a new class of fluorescent nanocrystals for manifold applications, from biophotonics to nanomedicine. Recent efforts in improving the photoluminescence quantum yield, the chemical stability and the biocompatibility turned them into a valid alternative to well established Cd-based nanocrystals. In vitro studies provided first evidence for the lower toxicity of In-based QDs. Nonetheless, an urgent need exists for further assessment of the potential toxic effects in vivo. Here we use the freshwater polyp Hydra vulgaris, a well-established model previously adopted to assess the toxicity of CdSe/CdS nanorods and CdTe QDs. A systematic multilevel analysis was carried out in vivo, ex vivo, and in vitro comparing toxicity end points of CdSe- and InP-based QDs, passivated by ZnSe/ZnS shells and surface functionalized with penicillamine. Final results demonstrate that both the chemical composition of the QD core (InP vs CdSe) and the shell play a crucial role for final outcomes. Remarkably, in absence of in vivo alterations, cell and molecular alterations revealed hidden toxicity aspects, highlighting the biosafety of InP-based nanocrystals and outlining the importance of integrated multilevel analyses for proper QDs risk assessment. info:eu-repo/grantAgreement/EC/H2020/660228/EU/Profiling gene expression in Hydra vulgaris following Gold Nanoparticle-mediated hyperthermia/HyHeat This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 660228-HyHeat info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 7.864 2019 ENVIRONMENTAL SCIENCES 15 / 265 = 0.057 2019 Q1 T1 ENGINEERING, ENVIRONMENTAL 6 / 53 = 0.113 2019 Q1 T1 2.704 2019 Chemistry (miscellaneous) 2019 Q1 Medicine (miscellaneous) 2019 Q1 Environmental Chemistry 2019 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Mattera, L. Bauduin, A. Miedziak, B. (orcid)0000-0002-2861-2469 Moros, M. Universidad de Zaragoza De Trizio, L. Tino, A. Reiss, P. Ambrosone, A. Tortiglione, C. 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 53, 7 (2019), 3938-3947 Environ. sci. technol. ENVIRONMENTAL SCIENCE & TECHNOLOGY 0013-936X 684380 http://zaguan.unizar.es/record/88215/files/texto_completo.pdf Postprint 316158 http://zaguan.unizar.es/record/88215/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:88215 articulos driver 2020-07-16-09:04:48 ARTICLE