88222 20200716101454.0 doi 10.1016/j.ejso.2019.03.017 sideral 111310 ART-2019-111310 eng Baena Fustegueras, J.A. Magnetic detection of sentinel lymph node in papillary thyroid carcinoma: The MAGIC-PAT study results 2019 Access copy available to the general public Unrestricted Introduction: Despite the controversy concerning sentinel lymph node biopsy (SLNB) in papillary thyroid carcinoma (PTC), successful detection rates can be achieved by radioguidance and vital dyeing. However, the drawbacks in both techniques are notable. Magnetic-guided SLNB (mSLNB) using superparamagnetic iron oxide (SPIO) nanoparticles is appealing as an alternative procedure. Materials and Methods: mSLNB using the Sentimag-Sienna System ® , total thyroidectomy and central compartment dissection (CCD) were performed on all PTC patients. Lymph node involvement was assessed by postoperative pathological examination. Results: From 2014 to 2016, 33 consecutive patients with PTC were enrolled in the study. A total of 20 patients met the eligibility. mSLNB succeeded in 16 patients, with a detection rate of 80%. A median of two SLN per patient were detected. A median of 10.5 non-sentinel lymph nodes (NSLN) from CCD were examined. Among the patients, 56.25% (9/16) had no metastatic nodes, while 12.5% (2/16) had exclusively SLN involvement. No false negative cases were found. The agreement between SLN and NSLN status was 87.5%. The prediction of NSLN involvement by SLN status showed 100% sensitivity, 81.8% specificity, 71.4% PPV and 100% NPV. Subsequently, mSLNB and the final pathological analysis would discriminate 43.75% (7/16) of patients who would certainly benefit from CCD whilst 56.25% of the total would confirm an unnecessary lymphadenectomy and avoid morbidity. Conclusion: mSLNB showed satisfactory performance in PTC with clinical-negative nodes. We have shown mSLNB to be a good predictor of central compartment status that can improve the staging and management of PTC patients. info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 3.959 2019 SURGERY 28 / 210 = 0.133 2019 Q1 T1 ONCOLOGY 90 / 244 = 0.369 2019 Q2 T2 1.389 2019 Medicine (miscellaneous) 2019 Q1 Surgery 2019 Q1 Oncology 2019 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion González, F.H. Calderó, S.G. de la Fuente Juárez, M.C. Ros López, S. Universidad de Zaragoza Riu, F.R. Petit, N.M. Álvarez, P.M. Torelló, A.L. Matias-Guiu, X. Olsina Kissler, J.J. 1004 090 Universidad de Zaragoza Dpto. Cirugía,Ginecol.Obstetr. Área Cirugía 19, 30 (2019), 342-7 Eur. j. surg. oncol. European Journal of Surgical Oncology 0748-7983 169115 http://zaguan.unizar.es/record/88222/files/texto_completo.pdf Postprint 43228 http://zaguan.unizar.es/record/88222/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:88222 articulos driver 2020-07-16-09:08:48 ARTICLE