000088259 001__ 88259
000088259 005__ 20200716101608.0
000088259 0247_ $$2doi$$a10.1007/s11864-019-0686-6
000088259 0248_ $$2sideral$$a116440
000088259 037__ $$aART-2019-116440
000088259 041__ $$aeng
000088259 100__ $$aMesia, Ricard
000088259 245__ $$aOpioid-Induced Constipation in Oncological Patients: New Strategies of Management
000088259 260__ $$c2019
000088259 5060_ $$aAccess copy available to the general public$$fUnrestricted
000088259 5203_ $$aOpinion statement Cancer-associated pain has traditionally been treated with opioid analgesics, often in escalating doses. Opioid-induced constipation (OIC) is a common problem associated with chronic use of opioid analgesics. Typical treatment strategies to alleviate constipation are based on dietary changes, exercise, and laxatives. However, laxatives have a nonspecific action and do not target underlying mechanisms of OIC. This article will review prevalent, clinical presentation and recommendations for the treatment of OIC. An independent literature search was carried out by the authors. We reviewed the literature for randomized controlled trials that studied the efficacy of laxatives, naloxone, and naloxegol in treating OIC. Newer strategies addressing the causal pathophysiology of OIC are needed for a more effective assessment and management of OIC. Finally, traditional recommended therapies are appraised and compared with the latest pharmacological developments. Future research should address whether naloxegol is more efficacious by its comparison directly with first-line treatments, including laxatives.
000088259 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000088259 590__ $$a3.9$$b2019
000088259 591__ $$aONCOLOGY$$b91 / 244 = 0.373$$c2019$$dQ2$$eT2
000088259 592__ $$a1.31$$b2019
000088259 593__ $$aPharmacology (medical)$$c2019$$dQ1
000088259 593__ $$aOncology$$c2019$$dQ2
000088259 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000088259 700__ $$aVirizuela Echaburu, Juan Antonio
000088259 700__ $$aGómez, Jose
000088259 700__ $$aSauri, Tamara
000088259 700__ $$aSerrano, Gloria
000088259 700__ $$aPujol, Eduardo$$uUniversidad de Zaragoza
000088259 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000088259 773__ $$g20, 12 (2019), 91 [14 pp.]$$pCURRENT TREATMENT OPTIONS IN ONCOLOGY$$tCURRENT TREATMENT OPTIONS IN ONCOLOGY$$x1527-2729
000088259 8564_ $$s257405$$uhttps://zaguan.unizar.es/record/88259/files/texto_completo.pdf$$yVersión publicada
000088259 8564_ $$s34120$$uhttps://zaguan.unizar.es/record/88259/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000088259 909CO $$ooai:zaguan.unizar.es:88259$$particulos$$pdriver
000088259 951__ $$a2020-07-16-09:55:36
000088259 980__ $$aARTICLE