Role of age and comorbidities in mortality of patients with infective endocarditis

Armiñanzas, C.; Kestler Hernández, M.; Méndez, I.; Alonso, M.D.M.; Pinilla, B.; García Mansilla, A.; Goikoetxea, J.; Montejo, M.; García, I.; Rodríguez García, R.; Ojeda, G.; Reus, S.; Irurzun Zuazabal, J.; Parra, J.A.; Rial Bastón, V.; Llinares, P.; Ojeda Burgos, G.; Climent, V.; Pinto, Á.; Goenaga, M.Á.; Gálvez Acebal, J.; Rodríguez, D.; Durán, M.D.C.; Voces, R.; Fernández Sánchez, F.; Bodro, M.; Rodrigo, D.; Martín-Dávila, P.; Verde Moreno, E.; Pereda, D.; Rodríguez, R.; Rodríguez-Créixems, M.; Bravo-Ferrer, J.M.; Llopis Pérez, J.; García Rosado, D.; Telenti Asensio, M.; Fariñas, M.C.; de Cueto, M.; Miró Meda, J.M.; León Arguero, V.; Cuende, A.M.; Crespo, A.; Miró, J.M.; Menárguez, M.C.; Carrasco, R.; Fita, G.; Vila, J.; Saldaña, A.; García Pavía, P.; Vázquez, P.; Ruiz Morales, J.; Almendro Delia, M.; Martínez Marcos, F.J.; Nassar, I.; Moreno, A.; Cuerpo Caballero, G.; Almela, M.; Rodríguez Esteban, Á.; Sitges, M.; Iruretagoyena, J.R.; Cuenca, J.; Rosas, G.; Reguera Iglesias, J.M.; Antorrena, I.; González Ramallo, V.; Agüero Balbín, J.; Cobo Belaustegui, M.; Pericás, J.M.; Muñoz, P.; Castelo, L.; Ambrosioni, J.; Zarauza, J.; Morales, I.; Vidal, B.; Teira, R.; Rovira, I.; Sandoval, E.; Martín Quirós, A.; Asensi Álvarez, V.; Hernández-Meneses, M.; Merino, E.; Valerio, M.; Lacalzada, J.; García López, M.V.; Rodríguez Bailón, I.; Ruiz, S.; Barquero, J.M.; Plata Ciezar, A.; Paré, C.; Gálvez-Acebal, J.; Sánchez, E.; Rodríguez Álvarez, R.; Idígoras, P.; Pajarón, M.; Georgieva, R.I.; Echeverría, T.; Bereciartua, E.; de la Hera, J.; Morales, C.; Celemín, D.; Nieto, J.; Pomar, J.L.; Rodríguez Mayo, M.; Castro, B.; Domínguez, F.; Blanco, M.J.; Rodríguez-Abella, H.; Bermejo, J.; Marco, F.; González, J.; Blanco, R.; Quintana, E.; Miguel Gómez, M.A.; Romero, M.; Orden, B.; López Menéndez, J.; Téllez, A.; Bouza, E.; Centella, T.; Fuster, D.; Soy, D.; López-Soria, L.; Ninot, S.; Vitoria, Y.; Gómez Izquierdo, R.; de la Torre Lima, J.; Iglesias Fraile, L.; Llamas, P.; Tolosana, J.M.; Brunet, M.; Gutiérrez-Cuadra, M.; Ramírez, J.; Moya, J.L.; Ramírez, U.; Oliva, E.; Palomo, C.; Moreno Torrico, A.; Izaguirre Yarza, A.; Sarralde, A.; Ramos, A.; Adán, I.; Marín, M.; Fernández Suárez, J.; Loeches, B.; Calvo Jambrina, R.; Costas, C.; Armiñanzas Castillo, C.; Martínez-Sellés, M.; Fuerte, A.; Araji, O.; Hidalgo Tenorio, C.; Gutiérrez Díez, J.; Campaña Lázaro, M.; Paya Martínez, B.; Hualde, A.M.; Boado, M.V.; Falces, C.; Arnaiz García, A.; Martínez Sellés, M.; Moreno, M.; Navas, E.; Reviejo, C.; Álvarez, N.; Matamala Adell, M.; Nicolás, D.; Gaminde, E.; Delgado Montero, A.; Kortajarena Urkola, X.; Iribarren, J.A.; García de la Mària, C.; Fariñas-Alvarez, C.; Fariñas-Álvarez, C.; Castelo Corral, L.; Sousa Regueiro, D.; Azqueta, M.; Cartañá, R.; Aramendi, J.; Mencia Bajo, P.; Rincón, C.; Martínez, F.J.; García Leoni, M.E.; del Río, A.; Noureddine, M.; Hermida, J.M.; Miguez Rey, E.; Fernández Cruz, A.; Plazas, J.; González-Rico, C.; Amado, C.

doi:10.1016/j.ejim.2019.03.006

000088275 001__ 88275
000088275 005__ 20210507081947.0
000088275 0247_ $$2doi$$a10.1016/j.ejim.2019.03.006
000088275 0248_ $$2sideral$$a111320
000088275 037__ $$aART-2019-111320
000088275 041__ $$aeng
000088275 100__ $$aArmiñanzas, C.
000088275 245__ $$aRole of age and comorbidities in mortality of patients with infective endocarditis
000088275 260__ $$c2019
000088275 5060_ $$aAccess copy available to the general public$$fUnrestricted
000088275 5203_ $$aPurpose: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. 
Methods: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015. Patients were stratified into three age groups:<65 years, 65 to 80 years, and = 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. 
Results: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 = 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients =80 years who underwent surgery were significantly lower compared with other age groups (14.3%, 65 years; 20.5%, 65-79 years; 31.3%, =80 years). In-hospital mortality was lower in the <65-year group (20.3%, <65 years;30.1%, 65-79 years;34.7%, =80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%, =80 years; p = 0.003).Independent predictors of mortality were age = 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI = 3 (HR:1.62; 95% CI:1.39–1.88), and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared, the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. 
Conclusion: There were no differences in the clinical presentation of IE between the groups. Age = 80 years, high comorbidity (measured by CCI), and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group.
000088275 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000088275 590__ $$a4.329$$b2019
000088275 591__ $$aMEDICINE, GENERAL & INTERNAL$$b26 / 165 = 0.158$$c2019$$dQ1$$eT1
000088275 592__ $$a1.017$$b2019
000088275 593__ $$aInternal Medicine$$c2019$$dQ2
000088275 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000088275 700__ $$aFariñas-Alvarez, C.
000088275 700__ $$aZarauza, J.
000088275 700__ $$aMuñoz, P.
000088275 700__ $$aGonzález Ramallo, V.
000088275 700__ $$aMartínez Sellés, M.
000088275 700__ $$aMiró Meda, J.M.
000088275 700__ $$aPericás, J.M.
000088275 700__ $$aGoenaga, M.Á.
000088275 700__ $$aOjeda Burgos, G.
000088275 700__ $$aRodríguez Álvarez, R.
000088275 700__ $$aCastelo Corral, L.
000088275 700__ $$aGálvez-Acebal, J.
000088275 700__ $$aMartínez Marcos, F.J.
000088275 700__ $$aFariñas, M.C.
000088275 700__ $$aFernández Sánchez, F.
000088275 700__ $$aNoureddine, M.
000088275 700__ $$aRosas, G.
000088275 700__ $$ade la Torre Lima, J.
000088275 700__ $$aAramendi, J.
000088275 700__ $$aBereciartua, E.
000088275 700__ $$aBlanco, M.J.
000088275 700__ $$aBlanco, R.
000088275 700__ $$aBoado, M.V.
000088275 700__ $$aCampaña Lázaro, M.
000088275 700__ $$aCrespo, A.
000088275 700__ $$aGoikoetxea, J.
000088275 700__ $$aIruretagoyena, J.R.
000088275 700__ $$aIrurzun Zuazabal, J.
000088275 700__ $$aLópez-Soria, L.
000088275 700__ $$aMontejo, M.
000088275 700__ $$aNieto, J.
000088275 700__ $$aRodrigo, D.
000088275 700__ $$aRodríguez, D.
000088275 700__ $$aRodríguez, R.
000088275 700__ $$aVitoria, Y.
000088275 700__ $$aVoces, R.
000088275 700__ $$aGarcía López, M.V.
000088275 700__ $$aGeorgieva, R.I.
000088275 700__ $$aOjeda, G.
000088275 700__ $$aRodríguez Bailón, I.
000088275 700__ $$aRuiz Morales, J.
000088275 700__ $$aCuende, A.M.
000088275 700__ $$aEcheverría, T.
000088275 700__ $$aFuerte, A.
000088275 700__ $$aGaminde, E.
000088275 700__ $$aIdígoras, P.
000088275 700__ $$aIribarren, J.A.
000088275 700__ $$aIzaguirre Yarza, A.
000088275 700__ $$aKortajarena Urkola, X.
000088275 700__ $$aReviejo, C.
000088275 700__ $$aCarrasco, R.
000088275 700__ $$aCliment, V.
000088275 700__ $$aLlamas, P.
000088275 700__ $$aMerino, E.
000088275 700__ $$aPlazas, J.
000088275 700__ $$aReus, S.
000088275 700__ $$aÁlvarez, N.
000088275 700__ $$aBravo-Ferrer, J.M.
000088275 700__ $$aCastelo, L.
000088275 700__ $$aCuenca, J.
000088275 700__ $$aLlinares, P.
000088275 700__ $$aMiguez Rey, E.
000088275 700__ $$aRodríguez Mayo, M.
000088275 700__ $$aSánchez, E.
000088275 700__ $$aSousa Regueiro, D.
000088275 700__ $$aMartínez, F.J.
000088275 700__ $$aAlonso, M.D.M.
000088275 700__ $$aCastro, B.
000088275 700__ $$aGarcía Rosado, D.
000088275 700__ $$aDurán, M.D.C.
000088275 700__ $$aMiguel Gómez, M.A.
000088275 700__ $$aLacalzada, J.
000088275 700__ $$aNassar, I.
000088275 700__ $$aPlata Ciezar, A.
000088275 700__ $$aReguera Iglesias, J.M.
000088275 700__ $$aAsensi Álvarez, V.
000088275 700__ $$aCostas, C.
000088275 700__ $$ade la Hera, J.
000088275 700__ $$aFernández Suárez, J.
000088275 700__ $$aIglesias Fraile, L.
000088275 700__ $$aLeón Arguero, V.
000088275 700__ $$aLópez Menéndez, J.
000088275 700__ $$aMencia Bajo, P.
000088275 700__ $$aMorales, C.
000088275 700__ $$aMoreno Torrico, A.
000088275 700__ $$aPalomo, C.
000088275 700__ $$aPaya Martínez, B.
000088275 700__ $$aRodríguez Esteban, Á.
000088275 700__ $$aRodríguez García, R.
000088275 700__ $$aTelenti Asensio, M.
000088275 700__ $$aAlmela, M.
000088275 700__ $$aAmbrosioni, J.
000088275 700__ $$aAzqueta, M.
000088275 700__ $$aBrunet, M.
000088275 700__ $$aBodro, M.
000088275 700__ $$aCartañá, R.
000088275 700__ $$aFalces, C.
000088275 700__ $$aFita, G.
000088275 700__ $$aFuster, D.
000088275 700__ $$aGarcía de la Mària, C.
000088275 700__ $$aHernández-Meneses, M.
000088275 700__ $$aLlopis Pérez, J.
000088275 700__ $$aMarco, F.
000088275 700__ $$aMiró, J.M.
000088275 700__ $$aMoreno, A.
000088275 700__ $$aNicolás, D.
000088275 700__ $$aNinot, S.
000088275 700__ $$aQuintana, E.
000088275 700__ $$aParé, C.
000088275 700__ $$aPereda, D.
000088275 700__ $$aPericás, J.M.
000088275 700__ $$aPomar, J.L.
000088275 700__ $$aRamírez, J.
000088275 700__ $$aRovira, I.
000088275 700__ $$aSandoval, E.
000088275 700__ $$aSitges, M.
000088275 700__ $$aSoy, D.
000088275 700__ $$aTéllez, A.
000088275 700__ $$aTolosana, J.M.
000088275 700__ $$aVidal, B.
000088275 700__ $$aVila, J.
000088275 700__ $$aAdán, I.
000088275 700__ $$aBermejo, J.
000088275 700__ $$aBouza, E.
000088275 700__ $$aCelemín, D.
000088275 700__ $$aCuerpo Caballero, G.
000088275 700__ $$aDelgado Montero, A.
000088275 700__ $$aFernández Cruz, A.
000088275 700__ $$aGarcía Mansilla, A.
000088275 700__ $$aGarcía Leoni, M.E.
000088275 700__ $$aKestler Hernández, M.
000088275 700__ $$aHualde, A.M.
000088275 700__ $$aMarín, M.
000088275 700__ $$aMartínez-Sellés, M.
000088275 700__ $$aMenárguez, M.C.
000088275 700__ $$aRincón, C.
000088275 700__ $$aRodríguez-Abella, H.
000088275 700__ $$aRodríguez-Créixems, M.
000088275 700__ $$aPinilla, B.
000088275 700__ $$aPinto, Á.
000088275 700__ $$aValerio, M.
000088275 700__ $$aVázquez, P.
000088275 700__ $$aVerde Moreno, E.
000088275 700__ $$aAntorrena, I.
000088275 700__ $$aLoeches, B.
000088275 700__ $$aMartín Quirós, A.
000088275 700__ $$aMoreno, M.
000088275 700__ $$aRamírez, U.
000088275 700__ $$aRial Bastón, V.
000088275 700__ $$aRomero, M.
000088275 700__ $$aSaldaña, A.
000088275 700__ $$aAgüero Balbín, J.
000088275 700__ $$aAmado, C.
000088275 700__ $$aArmiñanzas Castillo, C.
000088275 700__ $$aArnaiz García, A.
000088275 700__ $$aCobo Belaustegui, M.
000088275 700__ $$aFariñas, M.C.
000088275 700__ $$aFariñas-Álvarez, C.
000088275 700__ $$aGómez Izquierdo, R.
000088275 700__ $$aGarcía, I.
000088275 700__ $$aGonzález-Rico, C.
000088275 700__ $$aGutiérrez-Cuadra, M.
000088275 700__ $$aGutiérrez Díez, J.
000088275 700__ $$aPajarón, M.
000088275 700__ $$aParra, J.A.
000088275 700__ $$aSarralde, A.
000088275 700__ $$aTeira, R.
000088275 700__ $$aDomínguez, F.
000088275 700__ $$aGarcía Pavía, P.
000088275 700__ $$aGonzález, J.
000088275 700__ $$aOrden, B.
000088275 700__ $$aRamos, A.
000088275 700__ $$aCentella, T.
000088275 700__ $$aHermida, J.M.
000088275 700__ $$aMoya, J.L.
000088275 700__ $$aMartín-Dávila, P.
000088275 700__ $$aNavas, E.
000088275 700__ $$aOliva, E.
000088275 700__ $$adel Río, A.
000088275 700__ $$aRuiz, S.
000088275 700__ $$aHidalgo Tenorio, C.
000088275 700__ $$aAlmendro Delia, M.
000088275 700__ $$aAraji, O.
000088275 700__ $$aBarquero, J.M.
000088275 700__ $$aCalvo Jambrina, R.
000088275 700__ $$ade Cueto, M.
000088275 700__ $$aGálvez Acebal, J.
000088275 700__ $$aMéndez, I.
000088275 700__ $$aMorales, I.
000088275 700__ $$0(orcid)0000-0001-7482-2582$$aMatamala Adell, M.$$uUniversidad de Zaragoza
000088275 7102_ $$11004$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Cirugía
000088275 773__ $$g64 (2019), 63-71$$pEuropean Journal of Internal Medicine$$tEUROPEAN JOURNAL OF INTERNAL MEDICINE$$x0953-6205
000088275 8564_ $$s468185$$uhttps://zaguan.unizar.es/record/88275/files/texto_completo.pdf$$yPostprint
000088275 8564_ $$s53096$$uhttps://zaguan.unizar.es/record/88275/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000088275 909CO $$ooai:zaguan.unizar.es:88275$$particulos$$pdriver
000088275 951__ $$a2021-05-07-08:11:03
000088275 980__ $$aARTICLE

Repositorio Institucional de Documentos