Changes in retinal OCT and their correlations with neurological disability in early ALS patients, a follow-up study

Rojas, Pilar ; de Hoz, Rosa ; Ramírez, Ana I. ; Ferreras, Antonio (Universidad de Zaragoza) ; Salobrar-Garcia, Elena ; Muñoz-Blanco, José L. ; Urcelay-Segura, José L. ; Salazar, Juna J. ; Ramírez, José M.

Resumen: Background: To compare early visual changes in amyotrophic lateral sclerosis (ALS) patients with healthy controls in a baseline exploration, to follow-up the patients after 6 months, and to correlate these visual changes with neurological disability. Methods: All patients underwent a comprehensive neurological and ophthalmological examination. A linear mixed analysis and Bonferroni p-value correction were performed, testing four comparisons as follows: Control baseline vs. control follow-up, control baseline vs. ALS baseline, control follow-up vs. ALS follow-up, and ALS baseline vs. ALS follow-up. Results: The mean time from the diagnosis was 10.80 +/- 5.5 months. The analysis of the optical coherence tomography (OCT) showed: (1) In ALS baseline vs. control baseline, a macular significantly increased thickness of the inner macular ring temporal and inferior areas; (2) in ALS follow-up vs. ALS baseline, a significant macular thinning in the inner and outer macular ring inferior areas; (3) in ALS follow-up vs. ALS baseline, a significant peripapillary retinal nerve fiber layer (pRNFL) thinning in the superior and inferior quadrants; and (4) ALS patients showed a moderate correlation between some OCT pRNFL parameters and Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) score. Conclusion: The OCT showed retinal changes in patients with motoneuron disease and could serve as a complementary tool for studying ALS.

Idioma: Inglés

DOI: 10.3390/brainsci9120337

Año: 2019

Publicado en: Brain Sciences 9, 12 (2019), 337 [18 pp.]
ISSN: 2076-3425

Factor impacto JCR: 3.332 (2019)

Categ. JCR: NEUROSCIENCES rank: 113 / 270 = 0.419 (2019) - Q2 - T2

Factor impacto SCIMAGO: 0.999 - Neuroscience (miscellaneous) (Q2)

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Oftalmología (Dpto. Cirugía,Ginecol.Obstetr.)