88292 20250114155357.0 doi 10.3390/jcm8122209 sideral 116468 ART-2019-116468 eng Marco-Benedi, Victoria Aortic valvular disease in elderly subjects with heterozygous familial hypercholesterolemia: impact of lipid-lowering therapy 2019 Access copy available to the general public Unrestricted Hypercholesterolemia and statins are risk factors for aortic stenosis (AS) and vascular calcification, respectively. Whether heterozygous subjects with familial hypercholesterolemia (HeFH) treated with statins are at risk of AS is unknown. We study the prevalence of AS, aortic valve calcification (AoVC), and aortic sclerosis (ASc) in elderly subjects with HeFH in a prolonged statin treatment. Case-control study, cases were adults >= 65 years of age with a genetic diagnosis of HeFH, LDLc >220 mg/dl, and statin treatment >= 5 years. Controls were relatives of HeFH patients, with LDLc <190 mg/dl. Participants underwent a cardiac ultrasound for aortic valve analysis. We studied 205 subjects, 112 HeFH and 93 controls, with mean age 71.8(6.5) years and 70.0(7.3) years, respectively. HeHF, with respect to controls, presented greater gradients of aortic transvalvular pressure, 7.4(7.3) mmHg versus 5.0(2.8) mmHg, and maximum aortic velocity, 1.7(0.7) m/s versus 1.5(0.4) m/s, and lower aortic valve opening area, 2.0(0.7) cm(2) versus 2.4(0.6) cm(2) (all p < 0.05). AoVC and ASc were also more prevalent in HeFH (p < 0.05 between groups). Moderate/severe AS prevalence was higher among HeFH: 7.1% versus 1.1% (age- and sex-adjusted odds ratio (OR) 8.33, p = 0.03). Independent risk factors for aortic valve disease in HeFH were age and LDLc before treatment. The number of years under statin treatment was not associated with any aortic valve measurement. Subjects >= 65 years with HeFH in prolonged statin treatment show more aortic valvular disease and higher frequency of AS than controls. Life-long elevated LDLc exposure, rather than time of exposure to statins, explains this higher risk. info:eu-repo/grantAgreement/ES/MINECO/PI15-01983 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.303 2019 MEDICINE, GENERAL & INTERNAL 36 / 165 = 0.218 2019 Q1 T1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Laclaustra, Martín (orcid)0000-0003-3963-0846 Casado-Domínguez, Juan M. Villa-Pobo, Rosa Mateo-Gallego, Rocío Universidad de Zaragoza (orcid)0000-0001-6650-8294 Sánchez-Hernández, Rosa M. Blanco Nuez, Marta Ortega-Martínez de Victoria, Emilio Sitges, Marta Pedro-Botet, Juan Puzo, José Universidad de Zaragoza (orcid)0000-0002-1309-4363 Villarroel, Teresa Civeira, Fernando Universidad de Zaragoza (orcid)0000-0001-7043-0952 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 8, 12 (2019), 2209 [13 pp.] J. clin.med. Journal of Clinical Medicine 2077-0383 899323 http://zaguan.unizar.es/record/88292/files/texto_completo.pdf Versión publicada 474977 http://zaguan.unizar.es/record/88292/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:88292 articulos driver 2025-01-14-15:51:53 ARTICLE