000088329 001__ 88329
000088329 005__ 20210121114533.0
000088329 0247_ $$2doi$$a10.1210/jc.2014-4409
000088329 0248_ $$2sideral$$a90412
000088329 037__ $$aART-2015-90412
000088329 041__ $$aeng
000088329 100__ $$aLedesma, Marta
000088329 245__ $$aAssociation of ferritin elevation and metabolic syndrome in males. Results from the Aragon Workers' Health Study (AWHS)
000088329 260__ $$c2015
000088329 5060_ $$aAccess copy available to the general public$$fUnrestricted
000088329 5203_ $$aContext: Ferritin concentration is associated with metabolic syndrome, but the possibility of a nonlinear association has never been explored.
Objective: This study aimed to examine the relationship between serum ferritin levels and the metabolic syndrome in Spanish adult males.
Design: This was a cross-sectional analysis of baseline data from the Aragon Workers' Health Study.
Setting: Healthy workers from a factory were studied during their annual checkup.
Participants: Spanish male adults (n = 3386) between the ages of 19 and 65 years participated. We excluded participants with ferritin > 500 µg/L, ferritin < 12 µg/L, or C-reactive protein > 10 mg/L.
Main Outcome Measure: Metabolic syndrome was defined according to the 2009 consensus definition from the Joint Interim Statement of several international societies.
Results: Metabolic syndrome prevalence was 27.1%. We found a positive association between elevated iron stores, measured as serum ferritin concentration, and metabolic syndrome and its criteria. Participants within the highest serum ferritin quintile had a higher risk than those in the lowest quintile for central obesity (odds ratio [OR], 1.88; 95% confidence interval [CI], 1.46–2.42), hypertriglyceridemia (OR, 2.15; 95% CI, 1.69–2.74), and metabolic syndrome (OR, 1.92; 95% CI, 1.48–2.49). The association was nonlinear and occurred at serum ferritin concentrations > 100 µg/L (~ 33th percentile). Ferritin was also associated with insulin resistance, measured by homeostatic model assessment–insulin resistance (HOMA-IR) (P trend < .001).
Conclusions: Our findings suggest that serum ferritin is significantly associated with metabolic syndrome and its criteria (especially central obesity and hypertriglyceridemia), suggesting that ferritin could be an early marker of metabolic damage in the development of metabolic syndrome.
000088329 536__ $$9info:eu-repo/grantAgreement/ES/FIS/PI10-00021$$9info:eu-repo/grantAgreement/ES/ISCIII-FIS/CP08-00112$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI12-01434$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI14-00009$$9info:eu-repo/grantAgreement/ES/ISCIII/PI12-01703
000088329 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000088329 590__ $$a5.531$$b2015
000088329 591__ $$aENDOCRINOLOGY & METABOLISM$$b16 / 131 = 0.122$$c2015$$dQ1$$eT1
000088329 592__ $$a3.071$$b2015
000088329 593__ $$aBiochemistry$$c2015$$dQ1
000088329 593__ $$aBiochemistry (medical)$$c2015$$dQ1
000088329 593__ $$aMedicine (miscellaneous)$$c2015$$dQ1
000088329 593__ $$aEndocrinology$$c2015$$dQ1
000088329 593__ $$aEndocrinology, Diabetes and Metabolism$$c2015$$dQ1
000088329 593__ $$aClinical Biochemistry$$c2015$$dQ1
000088329 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000088329 700__ $$aHurtado-Roca, Yamilee
000088329 700__ $$aLeon, Montserrat
000088329 700__ $$0(orcid)0000-0002-8791-1901$$aGiraldo, Pilar
000088329 700__ $$0(orcid)0000-0001-8807-9187$$aPocovi, Miguel$$uUniversidad de Zaragoza
000088329 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, Fernando$$uUniversidad de Zaragoza
000088329 700__ $$aGuallar, Eliseo
000088329 700__ $$aOrdovas, José María
000088329 700__ $$0(orcid)0000-0002-9887-2629$$aCasasnovas, José Antonio.$$uUniversidad de Zaragoza
000088329 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, Martín
000088329 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000088329 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000088329 773__ $$g100, 5 (2015), 2081-2089$$pJ. clin. endocrinol. metab.$$tThe journal of clinical endocrinology and metabolism$$x0021-972X
000088329 8564_ $$s190890$$uhttps://zaguan.unizar.es/record/88329/files/texto_completo.pdf$$yVersión publicada
000088329 8564_ $$s31367$$uhttps://zaguan.unizar.es/record/88329/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000088329 909CO $$ooai:zaguan.unizar.es:88329$$particulos$$pdriver
000088329 951__ $$a2021-01-21-11:12:03
000088329 980__ $$aARTICLE