000088399 001__ 88399
000088399 005__ 20200716101603.0
000088399 0247_ $$2doi$$a10.1093/ecco-jcc/jjz070
000088399 0248_ $$2sideral$$a114821
000088399 037__ $$aART-2019-114821
000088399 041__ $$aeng
000088399 100__ $$aChaparro, M.
000088399 245__ $$aEffectiveness and Safety of the Switch from Remicade® to CT-P13 in Patients with Inflammatory Bowel Disease
000088399 260__ $$c2019
000088399 5060_ $$aAccess copy available to the general public$$fUnrestricted
000088399 5203_ $$aBACKGROUND AND AIMS: To evaluate the clinical outcomes in patients with IBD after switching from Remicade® to CT-P13 in comparison with patients who maintain Remicade®. METHODS: Patients under Remicade® who were in clinical remission with standard dosage at study entry were included. The ''switch cohort'' [SC] comprised patients who made the switch from Remicade® to CT-P13, and the ''non-switch'' cohort [NC] patients remained under Remicade®. RESULTS: A total of 476 patients were included: 199 [42%] in the SC and 277 [58%] in the NC. The median follow-up was 18 months in the SC and 23 months in the NC [p < 0.01]. Twenty-four out of 277 patients relapsed in the NC; the incidence of relapse was 5% per patient-year. The cumulative incidence of relapse was 2% at 6 months and 10% at 24 months in this group. Thirty-eight out of 199 patients relapsed in the SC; the incidence rate of relapse was 14% per patient-year. The cumulative incidence of relapse was 5% at 6 months and 28% at 24 months. In the multivariate analysis, the switch to CT-P13 was associated with a higher risk of relapse (HR = 3.5, 95% confidence interval [CI] = 2-6). Thirteen percent of patients had adverse events in the NC, compared with 6% in the SC [p < 0.05]. CONCLUSIONS: Switching from Remicade® to CT-P13 might be associated with a higher risk of clinical relapse, although this fact was not supported in our study by an increase in objective markers of inflammation. The nocebo effect might have influenced this result. Switching from Remicade® to CT-P13 was safe.
000088399 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FI17-00143$$9info:eu-repo/grantAgreement/ES/ISCIII/PI13-00041
000088399 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000088399 590__ $$a8.658$$b2019
000088399 591__ $$aGASTROENTEROLOGY & HEPATOLOGY$$b9 / 88 = 0.102$$c2019$$dQ1$$eT1
000088399 592__ $$a2.859$$b2019
000088399 593__ $$aMedicine (miscellaneous)$$c2019$$dQ1
000088399 593__ $$aGastroenterology$$c2019$$dQ1
000088399 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000088399 700__ $$aGarre, A.
000088399 700__ $$aGuerra, Veloz, M.F.
000088399 700__ $$aVázquez Morón, J.M.
000088399 700__ $$aDe Castro, M.L.
000088399 700__ $$aLeo, E.
000088399 700__ $$aRodriguez, E.
000088399 700__ $$aCarbajo, A.Y.
000088399 700__ $$aRiestra, S.
000088399 700__ $$aJiménez, I.
000088399 700__ $$aCalvet, X.
000088399 700__ $$aBujanda, L.
000088399 700__ $$aRivero, M.
000088399 700__ $$0(orcid)0000-0003-0076-3529$$aGomollón, F.$$uUniversidad de Zaragoza
000088399 700__ $$aBenítez, J.M.
000088399 700__ $$aBermejo, F.
000088399 700__ $$aAlcaide, N.
000088399 700__ $$aGutiérrez, A.
000088399 700__ $$aMañosa, M.
000088399 700__ $$aIborra, M.
000088399 700__ $$aLorente, R.
000088399 700__ $$aRojas-Feria, M.
000088399 700__ $$aBarreiro-de Acosta, M.
000088399 700__ $$aKolle, L.
000088399 700__ $$aVan Domselaar, M.
000088399 700__ $$aAmo, V.
000088399 700__ $$aArgüelles, F.
000088399 700__ $$aRamírez, E.
000088399 700__ $$aMorell, A.
000088399 700__ $$aBernardo, D.
000088399 700__ $$aGisbert, J.P.
000088399 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000088399 773__ $$g13, 11 (2019), 1380-1386$$pJournal of Crohns & Colitis$$tJournal of Crohn's and Colitis$$x1873-9946
000088399 8564_ $$s264973$$uhttps://zaguan.unizar.es/record/88399/files/texto_completo.pdf$$yPostprint
000088399 8564_ $$s62475$$uhttps://zaguan.unizar.es/record/88399/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000088399 909CO $$ooai:zaguan.unizar.es:88399$$particulos$$pdriver
000088399 951__ $$a2020-07-16-09:53:45
000088399 980__ $$aARTICLE