88448 20240111111737.0 doi 10.1080/10408398.2019.1677554 sideral 115062 ART-2020-115062 eng Lamiquiz-Moneo, Itziar (orcid)0000-0002-9647-0108 Effect of bergamot on lipid profile in humans: A systematic review 2020 Access copy available to the general public Unrestricted Dyslipidemia is a well-established modifiable cardiovascular risk. Although statins can reduce LDLc by 50-60%, less than 20% of patients with high risk of CVD achieve LDL targets. The aim of this systematic review is to evaluate the effect of the nutraceutical, bergamot (Citrus bergamia), on lipid parameters in humans. PubMed, Embase, Cochrane Library, and Google Scholar databases were searched for interventional and observational studies investigating the effect of bergamot on lipid profile in humans. This systematic review retrieved a total of 442 studies of which 12 articles fulfilled the eligibility criteria and were included in the qualitative synthesis. Based on data, 75% of studies showed a significant decrease in total cholesterol, triglycerides and LDLc. The decrease in total cholesterol varied from 12.3% to 31.3%, from 7.6% to 40.8% in LDLc and from 11.5% to 39.5% in triglycerides. Eight trials reported HDLc increase after intervention with bergamot. Overall, a dose-dependent and possible synergistic effect when administering with statins can be deducted from these trials. It is essential to point out that studies had heterogeneous designs and scientific quality of studies was quite limited. Promising findings reveal an alternative therapeutic option in dyslipidemia management with bergamot supplementation, especially in subjects with statins intolerance. info:eu-repo/grantAgreement/ES/MINECO/PI12-01321 info:eu-repo/grantAgreement/ES/MINECO/PI13-02507 info:eu-repo/grantAgreement/ES/MINECO/PI15-01983 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 11.176 2020 NUTRITION & DIETETICS 3 / 87 = 0.034 2020 Q1 T1 FOOD SCIENCE & TECHNOLOGY 4 / 143 = 0.028 2020 Q1 T1 2.029 2020 Food Science 2020 Q1 Medicine (miscellaneous) 2020 Q1 Industrial and Manufacturing Engineering 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Giné-González, Jaume Alisente, Sonsoles Bea, Ana M. Pérez-Calahorra, Sofía Universidad de Zaragoza (orcid)0000-0002-1894-1621 Marco-Benedi, Victoria Baila-Rueda, Lucía Jarauta, Estíbaliz Universidad de Zaragoza (orcid)0000-0001-9142-0737 Cenarro, Ana Civeira, Fernando Universidad de Zaragoza (orcid)0000-0001-7043-0952 Mateo-Gallego, Rocío Universidad de Zaragoza (orcid)0000-0001-6650-8294 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 60, 18 (2020), 3133-3143 Crit. rev. food sci. nutr. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION 1040-8398 1691941 http://zaguan.unizar.es/record/88448/files/texto_completo.pdf Versión publicada 1275096 http://zaguan.unizar.es/record/88448/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:88448 articulos driver 2024-01-11-10:59:31 ARTICLE