88480 20210902121634.0 doi 10.3390/ijms21051881 sideral 117242 ART-2020-117242 eng Salillas, Sandra Universidad de Zaragoza (orcid)0000-0003-0195-5434 Flavodoxins as novel therapeutic targets against helicobacter pylori and other gastric pathogens 2020 Access copy available to the general public Unrestricted Flavodoxins are small soluble electron transfer proteins widely present in bacteria and absent in vertebrates. Flavodoxins participate in different metabolic pathways and, in some bacteria, they have been shown to be essential proteins representing promising therapeutic targets to fight bacterial infections. Using purified flavodoxin and chemical libraries, leads can be identified that block flavodoxin function and act as bactericidal molecules, as it has been demonstrated for Helicobacter pylori (Hp), the most prevalent human gastric pathogen. Increasing antimicrobial resistance by this bacterium has led current therapies to lose effectiveness, so alternative treatments are urgently required. Here, we summarize, with a focus on flavodoxin, opportunities for pharmacological intervention offered by the potential protein targets described for this bacterium and provide information on other gastrointestinal pathogens and also on bacteria from the gut microbiota that contain flavodoxin. The process of discovery and development of novel antimicrobials specific for Hp flavodoxin that is being carried out in our group is explained, as it can be extrapolated to the discovery of inhibitors specific for other gastric pathogens. The high specificity for Hp of the antimicrobials developed may be of help to reduce damage to the gut microbiota and to slow down the development of resistant Hp mutants. info:eu-repo/grantAgreement/ES/DGA/LMP30-18 info:eu-repo/grantAgreement/ES/MINECO/BFU2016-78232-P info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.923 2020 BIOCHEMISTRY & MOLECULAR BIOLOGY 67 / 297 = 0.226 2020 Q1 T1 CHEMISTRY, MULTIDISCIPLINARY 49 / 178 = 0.275 2020 Q2 T1 1.455 2020 Catalysis 2020 Q1 Computer Science Applications 2020 Q1 Inorganic Chemistry 2020 Q1 Spectroscopy 2020 Q1 Molecular Biology 2020 Q1 Organic Chemistry 2020 Q1 Physical and Theoretical Chemistry 2020 Q1 Medicine (miscellaneous) 2020 Q1 info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion Sancho, Javier Universidad de Zaragoza (orcid)0000-0002-2879-9200 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 21, 5 (2020), 1881 [26 pp.] Int. j. mol. sci. International Journal of Molecular Sciences 1661-6596 1682746 http://zaguan.unizar.es/record/88480/files/texto_completo.pdf Versión publicada 489482 http://zaguan.unizar.es/record/88480/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:88480 articulos driver 2021-09-02-08:54:56 ARTICLE