000088492 001__ 88492
000088492 005__ 20210930085403.0
000088492 0247_ $$2doi$$a10.1021/acs.jpcc.9b05371
000088492 0248_ $$2sideral$$a114027
000088492 037__ $$aART-2019-114027
000088492 041__ $$aeng
000088492 100__ $$0(orcid)0000-0002-9198-5882$$aMoreno Maldonado, Ana Carolina$$uUniversidad de Zaragoza
000088492 245__ $$aFree-Radical Formation by the Peroxidase-Like Catalytic Activity of MFe2O4 (M = Fe, Ni, and Mn) Nanoparticles
000088492 260__ $$c2019
000088492 5060_ $$aAccess copy available to the general public$$fUnrestricted
000088492 5203_ $$aFerrite magnetic nanoparticles (MNPs) have peroxidase-like activity and thus catalyze the decomposition of H2O2-producing reactive oxygen species (ROS). Increasingly important applications of these ferrite MNPs in biology and medicine require that their morphological, physicochemical, and magnetic properties need to be strictly controlled. Usually, the tuning of their magnetic properties is achieved by the replacement of Fe by other 3d metals, such as Mn or Ni. Here, we studied the catalytic activity of ferrite MNPs (MFe2O4, M = Fe2+/Fe3+, Ni, and Mn) with the mean diameter ranging from 10 to 12 nm. Peroxidase-like activity was studied by electron paramagnetic resonance (EPR) using the spin-trap 5, 5-dimethyl-1-pyrroline N-oxide at different pHs (4.8 and 7.4) and temperatures (25 and 40 °C). We identified an enhanced amount of hydroxyl (•OH) and perhydroxyl (•OOH) radicals for all samples, compared to a blank solution. Quantitative studies show that [•OH] is the dominant radical formed for Fe3O4, which is strongly reduced with the concomitant oxidation of Fe2+ or its substitution (Ni or Mn). A comparative analysis of the EPR data against in vitro production of ROS in microglial BV2 cell culture provided additional insights regarding the catalytic activity of ferrite MNPs, which should be considered if biomedical uses are intended. Our results contribute to a better understanding of the role played by different divalent ions in the catalytic activity of ferrite nanoparticles, which is very important because of their use in biomedical applications.
000088492 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E26$$9info:eu-repo/grantAgreement/EC/H2020/734187/EU/Spin conversion, logic storage in oxide-based electronics/SPICOLOST$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 734187-SPICOLOST$$9info:eu-repo/grantAgreement/ES/MINECO/MAT2016-78201-P
000088492 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000088492 590__ $$a4.189$$b2019
000088492 591__ $$aCHEMISTRY, PHYSICAL$$b57 / 159 = 0.358$$c2019$$dQ2$$eT2
000088492 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b44 / 103 = 0.427$$c2019$$dQ2$$eT2
000088492 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b90 / 314 = 0.287$$c2019$$dQ2$$eT1
000088492 592__ $$a1.477$$b2019
000088492 593__ $$aElectronic, Optical and Magnetic Materials$$c2019$$dQ1
000088492 593__ $$aEnergy (miscellaneous)$$c2019$$dQ1
000088492 593__ $$aSurfaces, Coatings and Films$$c2019$$dQ1
000088492 593__ $$aPhysical and Theoretical Chemistry$$c2019$$dQ1
000088492 593__ $$aNanoscience and Nanotechnology$$c2019$$dQ1
000088492 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000088492 700__ $$aWinkler, Elin L.
000088492 700__ $$aRaineri, Mariana
000088492 700__ $$0(orcid)0000-0002-0087-7780$$aToro Córdova, Alfonso$$uUniversidad de Zaragoza
000088492 700__ $$aRodríguez, Luis M.
000088492 700__ $$aTroiani, Horacio E.
000088492 700__ $$aMojica Pisciotti, Mary Luz
000088492 700__ $$aVasquez Mansilla, Marcelo
000088492 700__ $$aTobia, Dina
000088492 700__ $$aNadal, Marcela S.
000088492 700__ $$aTorres, Teobaldo E
000088492 700__ $$aDe Biasi, Emilio
000088492 700__ $$aRamos, Carlos A.
000088492 700__ $$0(orcid)0000-0003-1558-9279$$aGoya, Gerardo F.$$uUniversidad de Zaragoza
000088492 700__ $$aZysler, Roberto D.
000088492 700__ $$aLima, Enio
000088492 7102_ $$12003$$2395$$aUniversidad de Zaragoza$$bDpto. Física Materia Condensa.$$cÁrea Física Materia Condensada
000088492 773__ $$g123, 33 (2019), 20617-20627$$pJ. phys. chem., C$$tJournal of Physical Chemistry C$$x1932-7447
000088492 8564_ $$s1459829$$uhttps://zaguan.unizar.es/record/88492/files/texto_completo.pdf$$yPostprint
000088492 8564_ $$s558425$$uhttps://zaguan.unizar.es/record/88492/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000088492 909CO $$ooai:zaguan.unizar.es:88492$$particulos$$pdriver
000088492 951__ $$a2021-09-30-08:26:50
000088492 980__ $$aARTICLE