000088530 001__ 88530 000088530 005__ 20210902121705.0 000088530 0247_ $$2doi$$a10.2807/1560-7917.ES.2020.25.8.1900393 000088530 0248_ $$2sideral$$a117323 000088530 037__ $$aART-2020-117323 000088530 041__ $$aeng 000088530 100__ $$aVelasco, M. 000088530 245__ $$aScreening for Trypanosoma cruzi infection in immigrants and refugees: Systematic review and recommendations from the Spanish Society of Infectious Diseases and Clinical Microbiology 000088530 260__ $$c2020 000088530 5060_ $$aAccess copy available to the general public$$fUnrestricted 000088530 5203_ $$aBackgroundChagas disease has spread beyond its original borders on the American continent with migration. It can be transmitted from mother to child, through organ transplantation and transfusion of blood and blood products. It is necessary to determine when to screen for this infection.AimOur objective was to evaluate the appropriateness of screening for Trypanosoma cruzi infection in Latin American migrants and their descendants.MethodsWe reviewed the literature using rigorous criteria. The quality of evidence was ranked according to the GRADE classification. An evidence to decision framework was adopted to provide information on the most relevant aspects necessary to formulate recommendations.ResultsThe 33 studies evaluated revealed a prevalence of T. cruzi infection among Latin American migrants in Europe of 6.08% (95% confidence interval (CI): 3.24-9.69; 28 studies). Vertical transmission occurred in three of 100 live births (95% CI: 1-6; 13 studies). The prevalence of cardiovascular disease was 19% (95% CI: 13-27; nine studies), including only 1% severe cardiac events (95% CI: 0-2; 11 studies). The overall quality of evidence was low because of risk of bias in the studies and considerable heterogeneity of the evaluated populations. The recommendations took into account economic studies on the value of screening strategies and studies on acceptability of screening and knowledge of the disease in the affected population.ConclusionsWe identified five situations in which screening for T. cruzi infection is indicated. We recommend screening persons from endemic areas and children of mothers from these areas. 000088530 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000088530 590__ $$a6.307$$b2020 000088530 591__ $$aINFECTIOUS DISEASES$$b8 / 92 = 0.087$$c2020$$dQ1$$eT1 000088530 592__ $$a2.766$$b2020 000088530 593__ $$aEpidemiology$$c2020$$dQ1 000088530 593__ $$aVirology$$c2020$$dQ1 000088530 593__ $$aPublic Health, Environmental and Occupational Health$$c2020$$dQ1 000088530 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1 000088530 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000088530 700__ $$0(orcid)0000-0003-2928-6623$$aGimeno-Feliú, L.A.$$uUniversidad de Zaragoza 000088530 700__ $$aMolina, I. 000088530 700__ $$aSalas-Coronas, J. 000088530 700__ $$aSolà, I. 000088530 700__ $$aMonge-Maillo, B. 000088530 700__ $$aTorrús-Tendero, D. 000088530 700__ $$aCaylà, J. 000088530 700__ $$ade Guzmán, E.N. 000088530 700__ $$aArellano, J.P. 000088530 700__ $$aPérez-Molina, J.A. 000088530 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000088530 773__ $$g25, 8 (2020), 1900393 1-13$$pEurosurveillance$$tEurosurveillance$$x1560-7917 000088530 8564_ $$s331933$$uhttps://zaguan.unizar.es/record/88530/files/texto_completo.pdf$$yVersión publicada 000088530 8564_ $$s26864$$uhttps://zaguan.unizar.es/record/88530/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000088530 909CO $$ooai:zaguan.unizar.es:88530$$particulos$$pdriver 000088530 951__ $$a2021-09-02-09:16:45 000088530 980__ $$aARTICLE