88530 20210902121705.0 doi 10.2807/1560-7917.ES.2020.25.8.1900393 sideral 117323 ART-2020-117323 eng Velasco, M. Screening for Trypanosoma cruzi infection in immigrants and refugees: Systematic review and recommendations from the Spanish Society of Infectious Diseases and Clinical Microbiology 2020 Access copy available to the general public Unrestricted BackgroundChagas disease has spread beyond its original borders on the American continent with migration. It can be transmitted from mother to child, through organ transplantation and transfusion of blood and blood products. It is necessary to determine when to screen for this infection.AimOur objective was to evaluate the appropriateness of screening for Trypanosoma cruzi infection in Latin American migrants and their descendants.MethodsWe reviewed the literature using rigorous criteria. The quality of evidence was ranked according to the GRADE classification. An evidence to decision framework was adopted to provide information on the most relevant aspects necessary to formulate recommendations.ResultsThe 33 studies evaluated revealed a prevalence of T. cruzi infection among Latin American migrants in Europe of 6.08% (95% confidence interval (CI): 3.24-9.69; 28 studies). Vertical transmission occurred in three of 100 live births (95% CI: 1-6; 13 studies). The prevalence of cardiovascular disease was 19% (95% CI: 13-27; nine studies), including only 1% severe cardiac events (95% CI: 0-2; 11 studies). The overall quality of evidence was low because of risk of bias in the studies and considerable heterogeneity of the evaluated populations. The recommendations took into account economic studies on the value of screening strategies and studies on acceptability of screening and knowledge of the disease in the affected population.ConclusionsWe identified five situations in which screening for T. cruzi infection is indicated. We recommend screening persons from endemic areas and children of mothers from these areas. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 6.307 2020 INFECTIOUS DISEASES 8 / 92 = 0.087 2020 Q1 T1 2.766 2020 Epidemiology 2020 Q1 Virology 2020 Q1 Public Health, Environmental and Occupational Health 2020 Q1 Medicine (miscellaneous) 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion (orcid)0000-0003-2928-6623 Gimeno-Feliú, L.A. Universidad de Zaragoza Molina, I. Salas-Coronas, J. Solà, I. Monge-Maillo, B. Torrús-Tendero, D. Caylà, J. de Guzmán, E.N. Arellano, J.P. Pérez-Molina, J.A. 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 25, 8 (2020), 1900393 1-13 Eurosurveillance Eurosurveillance 1560-7917 331933 http://zaguan.unizar.es/record/88530/files/texto_completo.pdf Versión publicada 26864 http://zaguan.unizar.es/record/88530/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:88530 articulos driver 2021-09-02-09:16:45 ARTICLE