88534 20210902121657.0 doi 10.3390/nano10030539 sideral 116756 ART-2020-116756 eng Ramírez Jiménez, Rafael Surfactant-free synthesis and scalable purification of triangular gold nanoprisms with low non-specific cellular uptake 2020 Access copy available to the general public Unrestricted Gold nanoprisms possess remarkable optical properties that make them useful for medical biotechnology applications such as diagnosis and photothermal therapy. However, shape-selective synthesis of gold nanoprisms is not trivial and typically requires either toxic surfactants or time-consuming purification protocols, which can limit their applicability. Here, we show how triangular gold nanoprisms of different sizes can be purified by precipitation using the non-toxic glutathione ligand, thereby removing the need for toxic surfactants and bottleneck purification techniques. The protocol is amenable for direct scaling up as no instrumentation is required in the critical purification step. The new purification method provides a two-fold increased yield in gold nanoprisms compared to electrophoretic filtration, while providing nanoprisms of similar localized surface plasmon resonance wavelength. Crucially, the gold nanoprisms isolated using this methodology show fewer non-specific interactions with cells and lower cellular internalization, which paves the way for a higher selectivity in therapeutic applications. info:eu-repo/grantAgreement/ES/MEC/FPU014-06249 info:eu-repo/grantAgreement/ES/MINECO/BIO2017-84246-C2-1-R info:eu-repo/grantAgreement/ES/MINECO/RYC-2013-12570 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.076 2020 PHYSICS, APPLIED 35 / 160 = 0.219 2020 Q1 T1 NANOSCIENCE & NANOTECHNOLOGY 51 / 106 = 0.481 2020 Q2 T2 CHEMISTRY, MULTIDISCIPLINARY 55 / 178 = 0.309 2020 Q2 T1 MATERIALS SCIENCE, MULTIDISCIPLINARY 103 / 333 = 0.309 2020 Q2 T1 0.919 2020 Materials Science (miscellaneous) 2020 Q1 Chemical Engineering (miscellaneous) 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artiga, Álvaro (orcid)0000-0001-9475-6367 Mitchell, Scott G. Universidad de Zaragoza (orcid)0000-0003-4848-414X Martín Rapún, Rafael Universidad de Zaragoza (orcid)0000-0003-0702-8260 de la Fuente, Jesús M. 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 10, 3 (2020), 539 [10 pp.] Nanomaterials (Basel) Nanomaterials 2079-4991 2260621 http://zaguan.unizar.es/record/88534/files/texto_completo.pdf Versión publicada 483057 http://zaguan.unizar.es/record/88534/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:88534 articulos driver 2021-09-02-09:11:05 ARTICLE