88589 20210902121701.0 doi 10.3390/ijerph17041236 sideral 117316 ART-2020-117316 eng Romero-Blanco, Cristina Strength and endurance training in older women in relation to ACTN3 R577X and ACE I/D Polymorphisms 2020 Access copy available to the general public Unrestricted The purpose of this study is to analyze the effect of two genetic polymorphisms, ACTN3 R577X, and ACE I/D, on physical condition in a sample of active older women after a two-year training period. The sample was composed of 300 healthy women over the age of 60 who underwent a two-year training program. Adapted tests from the Senior Fitness Test were used. The genotyping of the polymorphisms was obtained from the participants’ DNA via buccal swabs. The analysis of the ACE polymorphism did not reveal differences between genotypes. The analysis of the R577X polymorphism showed a favorable effect for the ACTN3 XX genotype in tests for leg strength (p: 0.001) after training, compared to the other genotypes, and also in the analysis of the combined effect of the polymorphism (ACE II + ACTN3 RX/XX). The intragroup effect revealed an improvement in arm strength for carriers of the X allele after 24 months of training (p < 0.05). The endurance values significantly worsened in all study groups. Conclusions: The R577X polymorphism of ACTN3 may have an important role in capacities related to muscle strength, providing a beneficial effect for carriers of the X allele. info:eu-repo/grantAgreement/ES/ISCIII/CB16-10-00477 info:eu-repo/grantAgreement/ES/ISCIII/RETICEF-RD12-043-0002 info:eu-repo/grantAgreement/ES/UZ/2008-BIO-01 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.39 2020 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH 41 / 176 = 0.233 2020 Q1 T1 ENVIRONMENTAL SCIENCES 118 / 273 = 0.432 2020 Q2 T2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH 68 / 203 = 0.335 2020 Q2 T2 0.747 2020 Health, Toxicology and Mutagenesis 2020 Q2 Public Health, Environmental and Occupational Health 2020 Q2 Pollution 2020 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artiga-González, María Jesús Gómez-Cabello, Alba (orcid)0000-0001-6492-2512 Vila-Maldonado, Sara Casajús, José Antonio Universidad de Zaragoza (orcid)0000-0002-7215-6931 Ara, Ignacio Aznar, Susana 1006 245 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Educación Física y Depor. 17, 4 (2020), 1236 [10 pp.] Int. j. environ. res. public health International Journal of Environmental Research and Public Health 1661-7827 339106 http://zaguan.unizar.es/record/88589/files/texto_completo.pdf Versión publicada 485583 http://zaguan.unizar.es/record/88589/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:88589 articulos driver 2021-09-02-09:14:21 ARTICLE