000089261 001__ 89261 000089261 005__ 20231027130637.0 000089261 0247_ $$2doi$$a10.1016/j.repc.2014.07.008 000089261 0248_ $$2sideral$$a89574 000089261 037__ $$aART-2015-89574 000089261 041__ $$aeng 000089261 100__ $$aCabrerizo-García, José Luis 000089261 245__ $$aInfluence of gender on prognosis of acute coronary syndromes 000089261 260__ $$c2015 000089261 5060_ $$aAccess copy available to the general public$$fUnrestricted 000089261 5203_ $$aIntroduction Ischemic heart disease presents different features in men and women. We analyzed the relation between gender and prognosis in patients who had suffered a high-risk acute coronary syndrome (ACS). Methods This was a prospective analytical cohort study performed at Lozano Blesa University Hospital, Zaragoza, Spain, of 559 patients diagnosed with high-risk ACS with and without ST-segment elevation according to the American College of Cardiology/American Heart Association guidelines. The sample was divided into two groups by gender and differences in epidemiologic, laboratory, electrocardiographic and echocardiographic variables and treatment were recorded. A Cox's proportional hazard model was applied and 6-month mortality was analyzed as the main variable. Results The median age was 65.2±12.7 years, and 21.8% were women. Baseline characteristics in women were more unfavorable, with higher GRACE scores, older age, higher prevalence of hypertension, diabetes and heart failure, lower ejection fraction and more renal dysfunction at admission. Women suffered more adverse cardiovascular events (27.9% vs. 15.8%, p=0.002). Sixty-four patients died, 18.9% of the women vs. 9.4% of the men (p=0.004). After multivariate analysis, female gender did not present an independent relation with mortality. Hemoglobin level, renal function, ejection fraction and Killip class >1 presented significant differences. Conclusions Acute syndrome coronary in women has a worse prognosis than in men. Their adverse course is due to their baseline characteristics and not to their gender. 000089261 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000089261 590__ $$a0.873$$b2015 000089261 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b109 / 124 = 0.879$$c2015$$dQ4$$eT3 000089261 592__ $$a0.291$$b2015 000089261 593__ $$aCardiology and Cardiovascular Medicine$$c2015$$dQ3 000089261 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000089261 700__ $$0(orcid)0000-0003-2361-9941$$aPérez-Calvo, Juan Ignacio$$uUniversidad de Zaragoza 000089261 700__ $$0(orcid)0000-0002-2290-4807$$aZalba-Etayo, Begoña$$uUniversidad de Zaragoza 000089261 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000089261 773__ $$g34, 1 (2015), 43-50$$pRevista portuguesa de cardiologia$$tRevista portuguesa de cardiologia$$x0870-2551 000089261 8564_ $$s417756$$uhttps://zaguan.unizar.es/record/89261/files/texto_completo.pdf$$yVersión publicada 000089261 8564_ $$s67501$$uhttps://zaguan.unizar.es/record/89261/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000089261 909CO $$ooai:zaguan.unizar.es:89261$$particulos$$pdriver 000089261 951__ $$a2023-10-27-12:53:12 000089261 980__ $$aARTICLE