000089262 001__ 89262
000089262 005__ 20200616135723.0
000089262 0247_ $$2doi$$a10.3389/fnins.2018.00952
000089262 0248_ $$2sideral$$a117513
000089262 037__ $$aART-2018-117513
000089262 041__ $$aeng
000089262 100__ $$aMendoza, Cristhian
000089262 245__ $$aCotinine Plus Krill Oil Decreased Depressive Behavior, and Increased Astrocytes Survival in the Hippocampus of Mice Subjected to Restraint Stress
000089262 260__ $$c2018
000089262 5060_ $$aAccess copy available to the general public$$fUnrestricted
000089262 5203_ $$aRestraint stress (RS) is a condition affecting millions of people worldwide. The investigation of new therapies to alleviate the consequences of prolonged RS is much needed. Cotinine, a nicotine-derivative, has shown to prevent the decrease in cerebral synaptic density, working memory deficits, anxiety, and depressive-like behavior after prolonged restraint stress (RS) in mice. Furthermore, post-treatment with cotinine reduced the adverse effects of chronic RS on astrocyte survival and architecture. On the other hand, the nutritional supplement krill oil (KO), has shown to be beneficial in decreasing depressive-like behavior and oxidative stress. In this study, in the search for effective preventative treatments to be used in people subjected to reduced mobility, the effect of co-treatment with cotinine plus KO in mice subjected to prolonged RS was investigated. The results show that cotinine plus KO prevented the loss of astrocytes, the appearance of depressive-like behavior and cognitive impairment induced by RS. The use of the combination of cotinine plus KO was more effective than cotinine alone in preventing the depressive-like behavior in the restrained mice. The potential use of this combination to alleviate the psychological effects of reduced mobility is discussed.
000089262 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000089262 590__ $$a3.648$$b2018
000089262 591__ $$aNEUROSCIENCES$$b91 / 266 = 0.342$$c2018$$dQ2$$eT2
000089262 592__ $$a1.665$$b2018
000089262 593__ $$aNeuroscience (miscellaneous)$$c2018$$dQ1
000089262 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000089262 700__ $$aPerez-Urrutia, Nelson
000089262 700__ $$aAlvarez-Ricartes, Nathalie
000089262 700__ $$aBarreto, George E.
000089262 700__ $$0(orcid)0000-0001-7839-0350$$aPérez-Ordás, Raquel$$uUniversidad de Zaragoza
000089262 700__ $$aIarkov, Alex
000089262 700__ $$aEcheverria, Valentina
000089262 7102_ $$13001$$2187$$aUniversidad de Zaragoza$$bDpto. Expres.Music.Plást.Corp.$$cÁrea Didáctica Expres.Corporal
000089262 773__ $$g12 (2018), 952 [11 pp.]$$pFront. neurosci.$$tFrontiers in neuroscience$$x1662-4548
000089262 8564_ $$s1549888$$uhttps://zaguan.unizar.es/record/89262/files/texto_completo.pdf$$yVersión publicada
000089262 8564_ $$s29331$$uhttps://zaguan.unizar.es/record/89262/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000089262 909CO $$ooai:zaguan.unizar.es:89262$$particulos$$pdriver
000089262 951__ $$a2020-06-16-13:51:03
000089262 980__ $$aARTICLE