000089264 001__ 89264
000089264 005__ 20210902121601.0
000089264 0247_ $$2doi$$a10.1097/IAE.0000000000002576
000089264 0248_ $$2sideral$$a112759
000089264 037__ $$aART-2020-112759
000089264 041__ $$aeng
000089264 100__ $$0(orcid)0000-0003-0349-9997$$aPinilla Lozano, Maria Isabel$$uUniversidad de Zaragoza
000089264 245__ $$aChanges in total and inner retinal thicknesses in type 1 diabetes with no retinopathy after 8 years of follow-up
000089264 260__ $$c2020
000089264 5060_ $$aAccess copy available to the general public$$fUnrestricted
000089264 5203_ $$aPurpose:To evaluate changes in retinal layer thickness in patients with Type 1 diabetes with no diabetic retinopathy after 8 years of follow-up.
Methods:Ninety Type 1 diabetes and 60 control eyes were studied. Changes in the retinal nerve fiber layer, ganglion cell layer, and inner nuclear layer thicknesses in all Early Treatment Diabetic Retinopathy Study areas were evaluated.
Results:The mean ages were 42.93 ± 13.62 and 41.52 ± 13.05 years in the diabetic and control group, respectively. In 2009, total retinal thickness was higher in diabetic patients; differences were statistically significant in all except the nasal areas. In both groups, the mean foveal thickness remained the same during the 8 years. Among diabetic patients, there was a significant reduction in total retinal thickness in all areas excluding the outer temporal one; controls only in the inferior areas. The thickness loss was due to the thinning of the inner retinal layers (inner nuclear layer, ganglion cell layer, and retinal nerve fiber layer). The controls showed a significant diminution in the retinal nerve fiber layer and in the ganglion cell layer areas. The inner nuclear layer showed a diminution in the diabetes mellitus group.
Conclusion:Before the onset of diabetic retinopathy, Type 1 diabetes patients experience a diminution of their inner retinal layer thicknesses over time, supporting the hypothesis of retinal neurodegeneration.
000089264 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000089264 592__ $$a2.24$$b2020
000089264 593__ $$aOphthalmology$$c2020$$dQ1
000089264 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1
000089264 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000089264 700__ $$0(orcid)0000-0002-0084-6247$$aIdoipe Corta, Miriam$$uUniversidad de Zaragoza
000089264 700__ $$0(orcid)0000-0002-9261-0302$$aPerdices Royo, Lorena
000089264 700__ $$0(orcid)0000-0002-5621-1937$$aSanchez Cano, Ana Isabel$$uUniversidad de Zaragoza
000089264 700__ $$0(orcid)0000-0002-2987-6351$$aAcha Perez, Javier$$uUniversidad de Zaragoza
000089264 700__ $$aLopez Galvez, Maria Isabel
000089264 700__ $$0(orcid)0000-0003-2710-1875$$aOrduna Hospital, Elvira$$uUniversidad de Zaragoza
000089264 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000089264 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000089264 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000089264 773__ $$g40, 7 (2020), 1379 - 1386$$pRetina Phila. Pa.$$tRetina (Philadelphia, Pa.)$$x1539-2864
000089264 8564_ $$s306122$$uhttps://zaguan.unizar.es/record/89264/files/texto_completo.pdf$$yPostprint
000089264 8564_ $$s22341$$uhttps://zaguan.unizar.es/record/89264/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000089264 909CO $$ooai:zaguan.unizar.es:89264$$particulos$$pdriver
000089264 951__ $$a2021-09-02-08:34:55
000089264 980__ $$aARTICLE