89264 20250221102107.0 doi 10.1097/IAE.0000000000002576 sideral 112759 ART-2020-112759 eng Pinilla Lozano, Maria Isabel Universidad de Zaragoza (orcid)0000-0003-0349-9997 Changes in total and inner retinal thicknesses in type 1 diabetes with no retinopathy after 8 years of follow-up 2020 Access copy available to the general public Unrestricted Purpose:To evaluate changes in retinal layer thickness in patients with Type 1 diabetes with no diabetic retinopathy after 8 years of follow-up. Methods:Ninety Type 1 diabetes and 60 control eyes were studied. Changes in the retinal nerve fiber layer, ganglion cell layer, and inner nuclear layer thicknesses in all Early Treatment Diabetic Retinopathy Study areas were evaluated. Results:The mean ages were 42.93 ± 13.62 and 41.52 ± 13.05 years in the diabetic and control group, respectively. In 2009, total retinal thickness was higher in diabetic patients; differences were statistically significant in all except the nasal areas. In both groups, the mean foveal thickness remained the same during the 8 years. Among diabetic patients, there was a significant reduction in total retinal thickness in all areas excluding the outer temporal one; controls only in the inferior areas. The thickness loss was due to the thinning of the inner retinal layers (inner nuclear layer, ganglion cell layer, and retinal nerve fiber layer). The controls showed a significant diminution in the retinal nerve fiber layer and in the ganglion cell layer areas. The inner nuclear layer showed a diminution in the diabetes mellitus group. Conclusion:Before the onset of diabetic retinopathy, Type 1 diabetes patients experience a diminution of their inner retinal layer thicknesses over time, supporting the hypothesis of retinal neurodegeneration. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 4.256 2020 OPHTHALMOLOGY 10 / 62 = 0.161 2020 Q1 T1 2.24 2020 Ophthalmology 2020 Q1 Medicine (miscellaneous) 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Idoipe Corta, Miriam Universidad de Zaragoza (orcid)0000-0002-0084-6247 Perdices Royo, Lorena (orcid)0000-0002-9261-0302 Sanchez Cano, Ana Isabel Universidad de Zaragoza (orcid)0000-0002-5621-1937 Acha Perez, Javier Universidad de Zaragoza (orcid)0000-0002-2987-6351 Lopez Galvez, Maria Isabel Orduna Hospital, Elvira Universidad de Zaragoza (orcid)0000-0003-2710-1875 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1013 646 Universidad de Zaragoza Dpto. Cirugía Área Oftalmología 2002 647 Universidad de Zaragoza Dpto. Física Aplicada Área Óptica 40, 7 (2020), 1379 - 1386 Retina RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES 0275-004X 137949 http://zaguan.unizar.es/record/89264/files/texto_completo.pdf Postprint 2479081 http://zaguan.unizar.es/record/89264/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:89264 articulos driver 2025-02-21-10:19:06 ARTICLE